{"id":32206,"date":"2016-11-26T04:48:04","date_gmt":"2016-11-26T12:48:04","guid":{"rendered":"http:\/\/lifeboat.com\/blog\/2016\/11\/researchers-put-mouse-embryos-in-suspended-animation"},"modified":"2017-06-04T14:01:34","modified_gmt":"2017-06-04T21:01:34","slug":"researchers-put-mouse-embryos-in-suspended-animation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2016\/11\/researchers-put-mouse-embryos-in-suspended-animation","title":{"rendered":"Researchers put mouse embryos in suspended animation"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/researchers-put-mouse-embryos-in-suspended-animation.jpg\"><\/a><\/p>\n<p>Hitting the pause button on development in embryos has implications for understanding aging.<\/p>\n<hr>\n<p>UC San Francisco researchers have found a way to pause the development of early mouse embryos for up to a month in the lab, a finding with potential implications for assisted reproduction, regenerative medicine, aging, and even cancer, the authors say.<\/p>\n<p>The new study\u2014published online November 23, 2016 in <i>Nature <\/i>\u2014involved experiments with pre-implantation mouse embryos, called blastocysts. The researchers found that drugs that inhibit the activity a master regulator of <a href=\"http:\/\/medicalxpress.com\/tags\/cell+growth\/\" rel=\"tag\" class=\"\">cell growth<\/a> called mTOR can put these early embryos into a stable and reversible state of suspended animation.<\/p>\n<p>\u201cNormally, blastocysts only last a day or two, max, in the lab. But blastocysts treated with mTOR inhibitors could survive up to 4 weeks,\u201d said the study\u2019s lead author, Aydan Bulut-Karslioglu, PhD, a post-doctoral researcher in the lab of senior author Miguel Ramalho-Santos, PhD, who is an associate professor of obstetrics\/gynecology and reproductive sciences at UCSF.<\/p>\n<p><!-- Link: <a href=\"http:\/\/medicalxpress.com\/news\/2016-11-mouse-embryos-animation.html\">http:\/\/medicalxpress.com\/news\/2016&#45;11-mouse-embryos-animation.html<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hitting the pause button on development in embryos has implications for understanding aging. UC San Francisco researchers have found a way to pause the development of early mouse embryos for up to a month in the lab, a finding with potential implications for assisted reproduction, regenerative medicine, aging, and even cancer, the authors say. The [\u2026]<\/p>\n","protected":false},"author":370,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-32206","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/32206","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/370"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=32206"}],"version-history":[{"count":2,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/32206\/revisions"}],"predecessor-version":[{"id":65707,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/32206\/revisions\/65707"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=32206"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=32206"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=32206"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}