{"id":31200,"date":"2016-10-19T04:48:49","date_gmt":"2016-10-19T11:48:49","guid":{"rendered":"http:\/\/lifeboat.com\/blog\/2016\/10\/pgc-1%ce%b1-gene-therapy-slows-alzheimers-progression-in-mouse-model"},"modified":"2017-04-24T19:27:48","modified_gmt":"2017-04-25T02:27:48","slug":"pgc-1%ce%b1-gene-therapy-slows-alzheimers-progression-in-mouse-model","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2016\/10\/pgc-1%ce%b1-gene-therapy-slows-alzheimers-progression-in-mouse-model","title":{"rendered":"PGC-1\u03b1 Gene Therapy Slows Alzheimer\u2019s Progression in Mouse Model"},"content":{"rendered":"

<\/a><\/p>\n

PCG-1\u03b1 therapy shows promise in treating age-related decline.<\/p>\n

\n

It is always a good idea to look closely at the biochemistry involved in any potential Alzheimer\u2019s disease<\/a> therapy that shows promise in mouse models<\/a>. There is perhaps more uncertainty for Alzheimer\u2019s than most other age-related conditions when it comes to the degree to which the models are a useful representation of the disease state in humans \u2014 which might go some way towards explaining the promising failures that litter the field. In the research here, the authors are aiming to suppress a step in the generation of amyloid-\u03b2<\/a>, one of the proteins that aggregates in growing amounts and is associated with brain cell death in Alzheimer\u2019s disease. They achieve this goal using gene therapy<\/a> to increase the level of PGC-1\u03b1<\/a>, which in turn reduces the level of an enzyme<\/a> involved in the production of amyloid-\u03b2. Interestingly, increased levels of PGC-1\u03b1 have in the past been shown to produce modest life extension<\/a> in mice, along with some of the beneficial effects to health associated with calorie restriction<\/a>.<\/p>\n

\n

Quote:<\/p><\/blockquote>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

PCG-1\u03b1 therapy shows promise in treating age-related decline. It is always a good idea to look closely at the biochemistry involved in any potential Alzheimer\u2019s disease therapy that shows promise in mouse models. There is perhaps more uncertainty for Alzheimer\u2019s than most other age-related conditions when it comes to the degree to which the models [\u2026]<\/p>\n","protected":false},"author":370,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19,1495,269,47],"tags":[],"class_list":["post-31200","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry","category-health","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/31200","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/370"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=31200"}],"version-history":[{"count":3,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/31200\/revisions"}],"predecessor-version":[{"id":49716,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/31200\/revisions\/49716"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=31200"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=31200"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=31200"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}