{"id":28963,"date":"2016-08-15T14:47:05","date_gmt":"2016-08-15T21:47:05","guid":{"rendered":"http:\/\/lifeboat.com\/blog\/2016\/08\/anti-inflammatory-drug-reverses-memory-loss-in-alzheimers-disease-model-mice"},"modified":"2017-04-26T13:06:19","modified_gmt":"2017-04-26T20:06:19","slug":"anti-inflammatory-drug-reverses-memory-loss-in-alzheimers-disease-model-mice","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2016\/08\/anti-inflammatory-drug-reverses-memory-loss-in-alzheimers-disease-model-mice","title":{"rendered":"Anti-inflammatory drug reverses memory loss in Alzheimer\u2019s-disease-model mice"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/anti-inflammatory-drug-reverses-memory-loss-in-alzheimers-disease-model-mice.jpg\"><\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" style=\"display:none;\" class=\"\" title=\"Alzheimer's brain\" src=\"https:\/\/lifeboat.com\/blog.images\/anti-inflammatory-drug-reverses-memory-loss-in-alzheimers-disease-model-mice.jpg\" alt=\"\" width=\"323\" height=\"328\" \/><b><center>(credit: NIH National Institute on Aging)<\/center><\/b><\/p>\n<p>Anti-inflammatory drug <a href=\"https:\/\/en.wikipedia.org\/wiki\/Mefenamic_acid\" target=\"_blank\">mefenamic acid<\/a> completely reversed memory loss and brain inflammation in mice genetically engineered to develop symptoms of Alzheimer\u2019s disease and amyloid beta-induced memory loss, a team led by <a href=\"http:\/\/www.manchester.ac.uk\/research\/david.brough\/\" target=\"_blank\">David Brough<\/a>, PhD, from the University of Manchester has discovered.<\/p>\n<p>The non-steroidal anti-inflammatory drug (NSAID) drug targets an important inflammatory pathway called the NLRP3 inflammasome, which damages brain cells, according to Brough. This is the first time a drug has been shown to target this inflammatory pathway, highlighting its importance in the disease model, Brough said.<\/p>\n<p><!-- Link: <a href=\"http:\/\/www.kurzweilai.net\/anti-inflammatory-drug-reverses-memory-loss-in-alzheimers-disease-model-mice\">http:\/\/www.kurzweilai.net\/anti-inflammatory-drug-reverses-me...model-mice<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>(credit: NIH National Institute on Aging) Anti-inflammatory drug mefenamic acid completely reversed memory loss and brain inflammation in mice genetically engineered to develop symptoms of Alzheimer\u2019s disease and amyloid beta-induced memory loss, a team led by David Brough, PhD, from the University of Manchester has discovered. The non-steroidal anti-inflammatory drug (NSAID) drug targets an important [\u2026]<\/p>\n","protected":false},"author":362,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,412,269,47],"tags":[],"class_list":["post-28963","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-genetics","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/28963","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/362"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=28963"}],"version-history":[{"count":3,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/28963\/revisions"}],"predecessor-version":[{"id":56400,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/28963\/revisions\/56400"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=28963"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=28963"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=28963"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}