{"id":28878,"date":"2016-08-13T03:53:00","date_gmt":"2016-08-13T10:53:00","guid":{"rendered":"http:\/\/lifeboat.com\/blog\/2016\/08\/directly-reprogramming-a-cells-identity-with-gene-editing"},"modified":"2017-06-04T14:25:41","modified_gmt":"2017-06-04T21:25:41","slug":"directly-reprogramming-a-cells-identity-with-gene-editing","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2016\/08\/directly-reprogramming-a-cells-identity-with-gene-editing","title":{"rendered":"Directly reprogramming a cell\u2019s identity with gene editing"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/directly-reprogramming-a-cells-identity-with-gene-editing.jpg\"><\/a><\/p>\n<p>Researchers have used CRISPR\u2014a revolutionary new genetic engineering technique\u2014to convert cells isolated from mouse connective tissue directly into neuronal cells.<\/p>\n<p>In 2006, Shinya Yamanaka, a professor at the Institute for Frontier Medical Sciences at Kyoto University at the time, discovered how to revert adult <a href=\"http:\/\/phys.org\/tags\/connective+tissue+cells\/\" rel=\"tag\" class=\"\">connective tissue cells<\/a>, called fibroblasts, back into immature stem cells that could differentiate into any cell type. These so-called induced <a href=\"http:\/\/phys.org\/tags\/pluripotent+stem+cells\/\" rel=\"tag\" class=\"\">pluripotent stem cells<\/a> won Yamanaka the Nobel Prize in medicine just six years later for their promise in research and medicine.<\/p>\n<p>Since then, researchers have discovered other ways to convert cells between different types. This is mostly done by introducing many <a href=\"http:\/\/phys.org\/tags\/extra+copies\/\" rel=\"tag\" class=\"\">extra copies<\/a> of \u201cmaster switch\u201d genes that produce proteins that turn on entire genetic networks responsible for producing a particular cell type.<\/p>\n<p><!-- Link: <a href=\"http:\/\/phys.org\/news\/2016-08-reprogramming-cell-identity-gene.html\">http:\/\/phys.org\/news\/2016&#45;08-reprogramming-cell-identity-gene.html<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers have used CRISPR\u2014a revolutionary new genetic engineering technique\u2014to convert cells isolated from mouse connective tissue directly into neuronal cells. In 2006, Shinya Yamanaka, a professor at the Institute for Frontier Medical Sciences at Kyoto University at the time, discovered how to revert adult connective tissue cells, called fibroblasts, back into immature stem cells that [\u2026]<\/p>\n","protected":false},"author":367,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,412,47],"tags":[],"class_list":["post-28878","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-genetics","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/28878","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/367"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=28878"}],"version-history":[{"count":2,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/28878\/revisions"}],"predecessor-version":[{"id":66603,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/28878\/revisions\/66603"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=28878"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=28878"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=28878"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}