{"id":28803,"date":"2016-08-10T23:03:35","date_gmt":"2016-08-11T06:03:35","guid":{"rendered":"http:\/\/lifeboat.com\/blog\/2016\/08\/nanoparticle-delivers-cancer-drugs-to-tumor-blood-vessels"},"modified":"2017-06-04T14:26:27","modified_gmt":"2017-06-04T21:26:27","slug":"nanoparticle-delivers-cancer-drugs-to-tumor-blood-vessels","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2016\/08\/nanoparticle-delivers-cancer-drugs-to-tumor-blood-vessels","title":{"rendered":"Nanoparticle delivers cancer drugs to tumor blood vessels"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/nanoparticle-delivers-cancer-drugs-to-tumor-blood-vessels.jpg\"><\/a><\/p>\n<p>In a set of studies in mice bearing human tumors, nanoparticles designed to bind to a protein called P-selectin successfully delivered both chemotherapy drugs and targeted therapies to tumor blood vessels. Targeting the blood vessels improved the delivery of drugs to tumor tissue, causing the tumors to shrink and improving how long the mice lived.<\/p>\n<p>A tumor\u2019s blood vessels can serve as a barrier to engineered drug-delivery systems like nanoparticles, which may not be able to cross the blood vessel wall. However, the same blood vessels may express proteins\u2014such as P-selectin\u2014that researchers can potentially exploit, by engineering their nanoparticles to recognize and latch onto those proteins, which enables them to reach the tumor.<\/p>\n<p><img decoding=\"async\" style=\"display:none;\" itemprop=\"image\" src=\"https:\/\/lifeboat.com\/blog.images\/nanoparticle-delivers-cancer-drugs-to-tumor-blood-vessels.jpg\" alt=\"Fluorescence microscopy image showing P-selectin\u2013targeting nanoparticles penetrating lab-grown tumor tissue\" border=\"0\" align=\"middle\" \/><\/p>\n<p><!-- Link: <a href=\"http:\/\/www.nanowerk.com\/nanotechnology-news\/newsid=44205.php\">http:\/\/www.nanowerk.com\/nanotechnology-news\/newsid=44205.php<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a set of studies in mice bearing human tumors, nanoparticles designed to bind to a protein called P-selectin successfully delivered both chemotherapy drugs and targeted therapies to tumor blood vessels. Targeting the blood vessels improved the delivery of drugs to tumor tissue, causing the tumors to shrink and improving how long the mice lived. [\u2026]<\/p>\n","protected":false},"author":395,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,38],"tags":[],"class_list":["post-28803","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-engineering"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/28803","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/395"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=28803"}],"version-history":[{"count":2,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/28803\/revisions"}],"predecessor-version":[{"id":66631,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/28803\/revisions\/66631"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=28803"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=28803"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=28803"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}