{"id":25640,"date":"2016-05-12T20:02:24","date_gmt":"2016-05-13T03:02:24","guid":{"rendered":"http:\/\/lifeboat.com\/blog\/2016\/05\/gene-regulatory-mutation-linked-to-rare-childhood-cancer"},"modified":"2017-04-24T20:53:25","modified_gmt":"2017-04-25T03:53:25","slug":"gene-regulatory-mutation-linked-to-rare-childhood-cancer","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2016\/05\/gene-regulatory-mutation-linked-to-rare-childhood-cancer","title":{"rendered":"Gene regulatory mutation linked to rare childhood cancer"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/gene-regulatory-mutation-linked-to-rare-childhood-cancer.jpg\"><\/a><\/p>\n<p>Nice and interesting Gene Mutation Discovery.<\/p>\n<hr>\n<p>A single defect in a gene that codes for a histone \u2014 a \u201cspool\u201d that wraps idle DNA \u2014 is linked to pediatric cancers in a study published in the journal <em>Science<\/em>.<\/p>\n<p>\u201cUnlike most cancers that require multiple hits, we found that this particular mutation can form a tumor all by itself,\u201d says Peter W. Lewis, an assistant professor of biomolecular chemistry in the School of Medicine and Public Health at the University of Wisconsin-Madison.<\/p>\n<p>Histones derive their pattern from the same genome that they help to pack up and organize. \u201cA histone\u2019s day job is compacting the genome,\u201d says Lewis. \u201cThe histone takes six feet of DNA and packs it in something that is a few microns in diameter.\u201d<\/p>\n<p><!-- Link: <a href=\"https:\/\/www.sciencedaily.com\/releases\/2016\/05\/160512145459.htm\">https:\/\/www.sciencedaily.com\/releases\/2016\/05\/160512145459.htm<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nice and interesting Gene Mutation Discovery. A single defect in a gene that codes for a histone \u2014 a \u201cspool\u201d that wraps idle DNA \u2014 is linked to pediatric cancers in a study published in the journal Science. \u201cUnlike most cancers that require multiple hits, we found that this particular mutation can form a tumor [\u2026]<\/p>\n","protected":false},"author":395,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1495],"tags":[],"class_list":["post-25640","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/25640","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/395"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=25640"}],"version-history":[{"count":2,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/25640\/revisions"}],"predecessor-version":[{"id":50515,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/25640\/revisions\/50515"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=25640"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=25640"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=25640"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}