{"id":25114,"date":"2016-04-28T06:02:32","date_gmt":"2016-04-28T13:02:32","guid":{"rendered":"http:\/\/lifeboat.com\/blog\/2016\/04\/math-points-to-100-times-faster-mapping-of-gene-activity"},"modified":"2017-04-24T21:10:36","modified_gmt":"2017-04-25T04:10:36","slug":"math-points-to-100-times-faster-mapping-of-gene-activity","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2016\/04\/math-points-to-100-times-faster-mapping-of-gene-activity","title":{"rendered":"Math points to 100-times faster mapping of gene activity"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/math-points-to-100-times-faster-mapping-of-gene-activity.jpg\"><\/a><\/p>\n<p>New research by UCSF scientists could accelerate \u2013 by 10 to 100-fold \u2013 the pace of many efforts to profile gene activity, ranging from basic research into how to build new tissues from stem cells to clinical efforts to detect cancer or auto-immune diseases by profiling single cells in a tiny drop of blood.<\/p>\n<p>The study, published online April 27, 2016, in the journal <i>Cell Systems<\/i>, rigorously demonstrates how to extract high-quality information about the patterns of <a href=\"http:\/\/phys.org\/tags\/gene+expression\/\" rel=\"tag\" class=\"\">gene expression<\/a> in individual cells without using expensive and time-consuming <a href=\"http:\/\/phys.org\/tags\/deep+sequencing\/\" rel=\"tag\" class=\"\">deep-sequencing<\/a> technology. The paper\u2019s senior authors are Hana El-Samad, PhD, an associate professor of biochemistry and biophysics at UCSF, and Matt Thomson, PhD, a faculty fellow in UCSF\u2019s Center for Systems and Synthetic Biology.<\/p>\n<p>\u201cWe believe the implications are huge because of the fundamental tradeoff between depth of sequencing and throughput, or cost,\u201d said El-Samad. \u201cFor example, suddenly, one can think of profiling a whole tumor at the single cell level.\u201d<\/p>\n<p><!-- Link: <a href=\"http:\/\/phys.org\/news\/2016-04-math-times-faster-gene.html\">http:\/\/phys.org\/news\/2016&#45;04-math-times-faster-gene.html<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>New research by UCSF scientists could accelerate \u2013 by 10 to 100-fold \u2013 the pace of many efforts to profile gene activity, ranging from basic research into how to build new tissues from stem cells to clinical efforts to detect cancer or auto-immune diseases by profiling single cells in a tiny drop of blood. The [\u2026]<\/p>\n","protected":false},"author":395,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,19,2229],"tags":[],"class_list":["post-25114","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-chemistry","category-mathematics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/25114","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/395"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=25114"}],"version-history":[{"count":2,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/25114\/revisions"}],"predecessor-version":[{"id":50689,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/25114\/revisions\/50689"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=25114"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=25114"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=25114"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}