{"id":247193,"date":"2026-11-12T19:05:35","date_gmt":"2026-11-13T01:05:35","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/11\/this-longevity-molecule-extends-primate-lifespan-by-15-dr-adam-salmon"},"modified":"2026-11-12T19:05:35","modified_gmt":"2026-11-13T01:05:35","slug":"this-longevity-molecule-extends-primate-lifespan-by-15-dr-adam-salmon","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/11\/this-longevity-molecule-extends-primate-lifespan-by-15-dr-adam-salmon","title":{"rendered":"This Longevity Molecule Extends Primate Lifespan by 15% | Dr. Adam Salmon"},"content":{"rendered":"\n<p><iframe title=\"This Longevity Molecule Extends Primate Lifespan by 15% | Dr. Adam Salmon\" style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/K4TdhCa9VjQ?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>Dr. Adam Salmon, Associate Director of the Barshop Institute at UT Health San Antonio, reveals historic findings from the first long-term rapamycin trial in non-human primates. Discover how daily mTOR inhibition extends marmoset median lifespan by 10% to 15%, preserves kidney function, and why primate glucose metabolism responds differently to rapamycin than rodents.<\/p>\n<p>For deeper breakdowns of emerging longevity trials and key takeaways from our expert interviews, subscribe to the Modern Healthspan Briefing: <a href=\"https:\/\/modernhealthspan.substack.com\">https:\/\/modernhealthspan.substack.com<\/a>\u2026 Support Cellular Energy &amp; Mitochondrial Health: Optimize your metabolic pathways with Renue By Science Liposomal NAD+, GlyNAC, and longevity formulas: \ud83d\udc49 (10% off: MHS) <a href=\"https:\/\/tinyurl.com\/bdew4bfs\">https:\/\/tinyurl.com\/bdew4bfs<\/a> \u2014 NMN Powder \u2022 Lipo NR \u2022 Spermidine \ud83e\uddec SUPPORT THE CHANNEL &amp; LONGEVITY PARTNERS If you would like to support our channel please consider joining our Patreon: <img class=\"\" alt=\"\"> \/ modernhealthspan Seeking Health (10% off: Richard10) <a href=\"https:\/\/crrnt.app\/SEEK\/-dm0MyrQ\">https:\/\/crrnt.app\/SEEK\/-dm0MyrQ<\/a> \u2014 Zinc Picolinate \u2022 Optimal D3+K2 Stemregen (15% off: MODERN) US only <a href=\"https:\/\/tinyurl.com\/45z968yr\">https:\/\/tinyurl.com\/45z968yr<\/a> AX3 Life (20% off: MODERN20) <a href=\"https:\/\/ax3.life\/MODERN20\">https:\/\/ax3.life\/MODERN20<\/a> \u2014 Astaxanthin n1o1 (10% off: Modern) <a href=\"https:\/\/tidd.ly\/3IczGRW\">https:\/\/tidd.ly\/3IczGRW<\/a> \u2014 Nitric Oxide Lozenges Qualia (15% off: MODERN) Creatine+ <a href=\"https:\/\/tinyurl.com\/mr3z35jd\">https:\/\/tinyurl.com\/mr3z35jd<\/a> \u2022 Senolytic <a href=\"https:\/\/bit.ly\/4jlaibe\">https:\/\/bit.ly\/4jlaibe<\/a> Wellness Extract (10% off: MODERNWE) <a href=\"http:\/\/wellnessextract.com\/RICHARDWE\">http:\/\/wellnessextract.com\/RICHARDWE<\/a> \u2014 Geranylgeraniol \u2022 Vit E 00:00 \u2014 Why Marmosets Are the Ideal Primate Model for Aging 05:35 \u2014 Landmark Marmoset Trial: Lifespan Extended 10\u201315% 08:45 \u2014 Healthspan Protection: Kidney Function &amp; Oral Health 11:17 \u2014 Dosing Strategy: Daily vs. Intermittent Protocols 13:09 \u2014 The Glucose Paradox: Blood Sugar in Primates vs. Mice 16:02 \u2014 mTORC1 vs. mTORC2: Why Mouse Liver Differs from Humans 18:40 \u2014 The Case for Pulsed Dosing &amp; Autophagy Cycling 20:43 \u2014 Unexpected Side Effects: Marmoset Joint &amp; Bone Data 22:46 \u2014 Cross-Species Hit Rate: Translating Mice to Humans 26:40 \u2014 Biomarkers, Metabolic Resilience &amp; Primate Lifespan 29:07 \u2014 Primate Research Infrastructure &amp; Nathan Shock Center 32:03 \u2014 Dismantling the Free Radical Theory of Aging 35:52 \u2014 Immune Resilience &amp; Barshop Institute Next Steps 39:45 \u2014 Reversing Side Effects &amp; Next-Gen mTORC1 Inhibitors 43:38 \u2014 Can AI Replace Non-Human Primate Aging Models? Can rapamycin safely slow biological aging and extend lifespan in primates? While rapamycin consistently extends mouse lifespan in the NIA\u2019s Interventions Testing Program (ITP), key questions remained regarding primate biology and metabolic safety. Dr. Adam Salmon discusses his landmark trial in common marmosets, demonstrating a 10% to 15% increase in median survival, mirroring early mouse longevity trials. Dr. Salmon breaks down the healthspan benefits observed in these primates, including preserved kidney function, delayed oral disease, and joint protection. He unpacks metabolic differences between rodents and primates, detailing how human liver physiology differs in glucose regulation, the mechanism behind mTORC1 versus mTORC2 inhibition, and why transient metabolic side effects reverse rapidly within one week of treatment cessation. Additionally, Dr. Salmon shares insights on the Free Radical Theory of Aging and mitochondrial resilience. If you would like to support our channel please consider joining our Patreon: <img class=\"\" alt=\"\"> \/ modernhealthspan \ud83d\udd2c Scientific Citations &amp; References Mentioned: 1. Salmon, A.B. et al. Long-term treatment with the mTOR inhibitor rapamycin extends lifespan and improves healthspan in common marmosets. Landmark Primate Trial \/ Barshop Institute. 2. Lamming, D.W., Salmon, A.B. et al. (2012). Depletion of mTOR and mLST8 uncouples longevity from rapamycin-induced changes in glucose homeostasis. Science, 335(6076): 1638\u20131643. PMID: 22,461,615 3. Marolf, B.A., Salmon, A.B. et al. (2024). Impact of long-term rapamycin treatment on age-related osteoarthritis in common marmoset. bioRxiv, DOI: 10.1101\/2024.05.14.594256 4. Bene, M. &amp; Salmon, A.B. (2023). Lifespan-extending compound interventions across laboratory animal model species. GeroScience, 45: 2153\u20132171. PMID: 36,780,031 5. Horvath, S., Salmon, A.B. et al. (2021). DNA methylation age analysis of rapamycin in common marmosets. GeroScience, 43: 2419\u20132428. PMID: 34,626,308 \ud83c\udf10 Connect with Dr. Adam Salmon: \u2022 Barshop Institute: <a href=\"https:\/\/barshop.uthscsa.edu\">https:\/\/barshop.uthscsa.edu<\/a> \u2022 Faculty Profile: <a href=\"https:\/\/uthscsa.edu\/medicine\/faculty\/.\">https:\/\/uthscsa.edu\/medicine\/faculty\/.<\/a>\u2026 \u26a0\ufe0f Medical Disclaimer: Modern Healthspan content is for educational and informational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult a qualified physician or healthcare provider before making changes to your health regimen, diet, or lifestyle. #Rapamycin #Longevity #Healthspan.<\/p>\n<p>\u26a1 Support Cellular Energy &amp; Mitochondrial Health:<br \/> Optimize your metabolic pathways with Renue By Science Liposomal NAD+, GlyNAC, and longevity formulas:<br \/> \ud83d\udc49 (10% off: MHS) <a href=\"https:\/\/tinyurl.com\/bdew4bfs\">https:\/\/tinyurl.com\/bdew4bfs<\/a> \u2014 NMN Powder \u2022 Lipo NR \u2022 Spermidine.<\/p>\n<p>\ud83e\uddec SUPPORT THE CHANNEL &amp; LONGEVITY PARTNERS<br \/> If you would like to support our channel please consider joining our Patreon: \/ modernhealthspan.<\/p>\n<p>Seeking Health (10% off: Richard10) <a href=\"https:\/\/crrnt.app\/SEEK\/-dm0MyrQ\">https:\/\/crrnt.app\/SEEK\/-dm0MyrQ<\/a> \u2014 Zinc Picolinate \u2022 Optimal D3+K2<br \/> Stemregen (15% off: MODERN) US only <a href=\"https:\/\/tinyurl.com\/45z968yr\">https:\/\/tinyurl.com\/45z968yr<\/a>.<br \/> AX3 Life (20% off: MODERN20) <a href=\"https:\/\/ax3.life\/MODERN20\">https:\/\/ax3.life\/MODERN20<\/a> \u2014 Astaxanthin.<br \/> n1o1 (10% off: Modern) <a href=\"https:\/\/tidd.ly\/3IczGRW\">https:\/\/tidd.ly\/3IczGRW<\/a> \u2014 Nitric Oxide Lozenges.<br \/> Qualia (15% off: MODERN) Creatine+ <a href=\"https:\/\/tinyurl.com\/mr3z35jd\">https:\/\/tinyurl.com\/mr3z35jd<\/a> \u2022 Senolytic <a href=\"https:\/\/bit.ly\/4jlaibe\">https:\/\/bit.ly\/4jlaibe<\/a>.<br \/> Wellness Extract (10% off: MODERNWE) <a href=\"http:\/\/wellnessextract.com\/RICHARDWE\">http:\/\/wellnessextract.com\/RICHARDWE<\/a> \u2014 Geranylgeraniol \u2022 Vit E<\/p>\n<p>00:00 \u2014 Why Marmosets Are the Ideal Primate Model for Aging.<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2026\/11\/this-longevity-molecule-extends-primate-lifespan-by-15-dr-adam-salmon\">Continue reading \u201cThis Longevity Molecule Extends Primate Lifespan by 15% | Dr. Adam Salmon\u201d | &gt;<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Adam Salmon, Associate Director of the Barshop Institute at UT Health San Antonio, reveals historic findings from the first long-term rapamycin trial in non-human primates. Discover how daily mTOR inhibition extends marmoset median lifespan by 10% to 15%, preserves kidney function, and why primate glucose metabolism responds differently to rapamycin than rodents. For deeper [\u2026]<\/p>\n","protected":false},"author":388,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,32,269,6],"tags":[],"class_list":["post-247193","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-education","category-life-extension","category-robotics-ai"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/247193","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/388"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=247193"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/247193\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=247193"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=247193"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=247193"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}