{"id":247185,"date":"2026-11-12T11:18:43","date_gmt":"2026-11-12T17:18:43","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/11\/human-basal-ganglia-atlas-reveals-how-genes-are-regulated-in-individual-cells"},"modified":"2026-11-12T11:18:43","modified_gmt":"2026-11-12T17:18:43","slug":"human-basal-ganglia-atlas-reveals-how-genes-are-regulated-in-individual-cells","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/11\/human-basal-ganglia-atlas-reveals-how-genes-are-regulated-in-individual-cells","title":{"rendered":"Human basal ganglia atlas reveals how genes are regulated in individual cells"},"content":{"rendered":"\n<p>Salk Institute researchers have contributed to a landmark accomplishment in neuroscience: a 3D atlas of the human basal ganglia with single-cell genetic and epigenetic detail, published as a <a href=\"https:\/\/www.cell.com\/consortium\/bican-basal-ganglia-atlas\" target=\"_blank\">collection of 28 papers across Cell Press journals<\/a>. The basal ganglia are a group of nerve cells that sit deep in the brain, where they control key functions like learning, emoting and moving. Basal ganglia dysfunction can lead to conditions like Parkinson\u2019s disease, Huntington\u2019s disease, Tourette syndrome and addiction.<\/p>\n<p>The atlas offers a new window into the brain, through which scientists can identify and pinpoint each cell in the human basal ganglia. This comprehensive database of brain cells and functions could be used to create personalized therapeutics, identify relevant epigenetic and genetic targets for gene-editing therapies, and link genetic risks with particular cell types for more targeted, effective treatments.<\/p>\n<p>The effort is part of the Brain Research Through Advancing Innovative Neurotechnologies Initiative, or the BRAIN Initiative, a massive collaboration launched in 2014 that brings together scientists to \u201crevolutionize our understanding of the human brain.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Salk Institute researchers have contributed to a landmark accomplishment in neuroscience: a 3D atlas of the human basal ganglia with single-cell genetic and epigenetic detail, published as a collection of 28 papers across Cell Press journals. The basal ganglia are a group of nerve cells that sit deep in the brain, where they control key [\u2026]<\/p>\n","protected":false},"author":630,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,47],"tags":[],"class_list":["post-247185","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/247185","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/630"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=247185"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/247185\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=247185"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=247185"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=247185"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}