A KAIST-led research team has found that a protein involved in gene regulation can suppress the harmful aggregation of amyloid-beta, a peptide associated with Alzheimer\u2019s disease. The approach also reduced the toxicity of protein aggregates that had already formed. In experiments using a mouse model of Alzheimer\u2019s disease, the treatment reduced protein accumulation in the brain and improved recognition memory, suggesting a possible route toward new therapeutics.<\/p>\n
KAIST (President Choongsik Bae) announced on November 5 that the research team led by Professor Mi Hee Lim from the Department of Chemistry identified a new approach to controlling the aggregation and toxicity of amyloid-beta. The study was conducted in collaboration with Professor Seung Jae Lee\u2019s team in the Department of Chemistry at Jeonbuk National University, Dr. Chul-Ho Lee and Dr. Kyoung-Shim Kim of the Korea Research Institute of Bioscience and Biotechnology (KRIBB), Dr. Young-Ho Lee of the Korea Basic Science Institute (KBSI), and Dr. Jiyong Park of the Institute for Basic Science (IBS).<\/p>\n
One of the hallmarks of Alzheimer\u2019s disease is the abnormal aggregation and accumulation of amyloid-beta in the brain. Toxic aggregates formed during this process can damage nerve cells. The team sought to suppress this harmful aggregation and reduce the toxicity of existing aggregates.<\/p>\n","protected":false},"excerpt":{"rendered":"
A KAIST-led research team has found that a protein involved in gene regulation can suppress the harmful aggregation of amyloid-beta, a peptide associated with Alzheimer\u2019s disease. The approach also reduced the toxicity of protein aggregates that had already formed. In experiments using a mouse model of Alzheimer\u2019s disease, the treatment reduced protein accumulation in the [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-246960","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/246960","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=246960"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/246960\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=246960"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=246960"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=246960"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}