(AKG), a key tricarboxylic acid cycle intermediate, is widely consumed as a dietary supplement by healthy individuals for its perceived anti-aging and performance-enhancing benefits. While its antidiabetic and anti-obesity effects have been reported under pathological conditions, the safety profile and mechanisms of long-term AKG intake in healthy animals remain largely unexplored. Here, we demonstrate that long-term AKG intake via food or drinking water markedly elevates hepatic triglyceride levels and induces steatosis in healthy mice by suppressing adipose triglyceride lipase (Atgl) activity. The lipid-droplet-associated protein, cell death-inducing DNA fragmentation factor 45-like effector C (Cidec), is an inhibitor of Atgl. We find that AKG stabilizes Cidec by attenuating tripartite-motif protein 21-mediated ubiquitination.<\/p>\n","protected":false},"excerpt":{"rendered":"
(AKG), a key tricarboxylic acid cycle intermediate, is widely consumed as a dietary supplement by healthy individuals for its perceived anti-aging and performance-enhancing benefits. While its antidiabetic and anti-obesity effects have been reported under pathological conditions, the safety profile and mechanisms of long-term AKG intake in healthy animals remain largely unexplored. Here, we demonstrate that [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1506,269],"tags":[],"class_list":["post-246954","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-food","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/246954","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=246954"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/246954\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=246954"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=246954"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=246954"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}