{"id":246927,"date":"2026-11-09T10:27:21","date_gmt":"2026-11-09T16:27:21","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/11\/parkinsons-may-be-driven-by-vicious-cycle-that-disrupts-brain-waste-drainage"},"modified":"2026-11-09T10:27:21","modified_gmt":"2026-11-09T16:27:21","slug":"parkinsons-may-be-driven-by-vicious-cycle-that-disrupts-brain-waste-drainage","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/11\/parkinsons-may-be-driven-by-vicious-cycle-that-disrupts-brain-waste-drainage","title":{"rendered":"Parkinson\u2019s may be driven by \u2018vicious cycle\u2019 that disrupts brain waste drainage"},"content":{"rendered":"\n<p>\u201cIt is a vicious cycle,\u201d says <a href=\"https:\/\/profiles.auckland.ac.nz\/justin-rustenhoven\">Justin Rustenhoven<\/a> at the University of Auckland in New Zealand. This may also help explain why Parkinson\u2019s disease is a progressive condition that worsens over time, he says.<\/p>\n<p>Parkinson\u2019s disease, which <a href=\"https:\/\/eur02.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.parkinson.org%2Funderstanding-parkinsons%2Fstatistics&data=05%7C02%7CAlexandra.Thompson%40newscientist.com%7C25cce0352f7c42839b3608de96015e57%7C0f3a4c644dc54a768d4152d85ca158a5%7C0%7C0%7C639113129822061291%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=VgSmwsSocjHzYvRpRlM8nPcSKhw8QnJ0WZwq7gAmrsk%3D&reserved=0\">affects more than 10 million people worldwide<\/a>, is characterised by a loss of neurons in brain regions that control movement. This causes symptoms such as tremor and muscle stiffness. The condition is thought to be caused by alpha-synuclein, which occurs naturally in the brain, misfolding and forming clumps that damage neurons.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u201cIt is a vicious cycle,\u201d says Justin Rustenhoven at the University of Auckland in New Zealand. This may also help explain why Parkinson\u2019s disease is a progressive condition that worsens over time, he says. Parkinson\u2019s disease, which affects more than 10 million people worldwide, is characterised by a loss of neurons in brain regions that [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-246927","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/246927","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=246927"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/246927\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=246927"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=246927"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=246927"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}