{"id":246892,"date":"2026-11-09T02:06:51","date_gmt":"2026-11-09T08:06:51","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/11\/treatment-revives-old-liver-cells-in-lab-study-may-help-prevent-alzheimers-and-heart-disease"},"modified":"2026-11-09T02:06:51","modified_gmt":"2026-11-09T08:06:51","slug":"treatment-revives-old-liver-cells-in-lab-study-may-help-prevent-alzheimers-and-heart-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/11\/treatment-revives-old-liver-cells-in-lab-study-may-help-prevent-alzheimers-and-heart-disease","title":{"rendered":"Treatment revives old liver cells in lab study, may help prevent Alzheimer\u2019s and heart disease"},"content":{"rendered":"\n<p>The liver\u2019s job of clearing harmful substances from the body is so essential that the organ may have implications for addressing unexpected diseases, including Alzheimer\u2019s and heart disease. A promising example comes from new Keck School of Medicine of USC research published in the Journal of Biological Chemistry.<\/p>\n<p>The study, conducted in aged rats, shows that an experimental drug called cinaciguat reverses effects of aging in the liver. This, in turn, may lower the risk of Alzheimer\u2019s disease and clogged arteries. The researchers also revealed what\u2019s behind that rejuvenation, including a specific biochemical pathway used for local communication between liver cells, which suggests a potential therapeutic target.<\/p>\n<p>\u201cWe need to do further translational work to see whether our findings might point to new therapies,\u201d said corresponding author Laurie DeLeve, M.D., Ph.D., professor and vice chair for scientific affairs in the USC Department of Medicine.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The liver\u2019s job of clearing harmful substances from the body is so essential that the organ may have implications for addressing unexpected diseases, including Alzheimer\u2019s and heart disease. A promising example comes from new Keck School of Medicine of USC research published in the Journal of Biological Chemistry. The study, conducted in aged rats, shows [\u2026]<\/p>\n","protected":false},"author":707,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19,269,47],"tags":[],"class_list":["post-246892","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/246892","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/707"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=246892"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/246892\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=246892"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=246892"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=246892"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}