{"id":246890,"date":"2026-11-08T22:14:46","date_gmt":"2026-11-09T04:14:46","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/11\/regulatable-in-vivo-gene-expression-via-adaptamers"},"modified":"2026-11-08T22:14:46","modified_gmt":"2026-11-09T04:14:46","slug":"regulatable-in-vivo-gene-expression-via-adaptamers","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/11\/regulatable-in-vivo-gene-expression-via-adaptamers","title":{"rendered":"Regulatable in vivo gene expression via adaptamers"},"content":{"rendered":"\n<p>Bryant et al. created adaptamers, 120 bp RNA sequences which act as regulatory elements of mRNAs so that translation only occurs in the presence of a small molecule inducer (tetracycline or doxycycline). They work by recruiting endogenous adenosine deaminases to edit out a stop codon only when the inducer stabilizes a stem loop structure. A very clever design with lots of promise for gene therapy!<\/p>\n<hr>\n<p>Bryant et al. develop adaptamers, compact RNA switches that use FDA-approved drugs to control gene expression by co-opting endogenous RNA-editing machinery rather than relying on foreign proteins. In mice, this approach safely tuned a metabolic hormone to reverse obesity, pointing to a simpler path toward programmable, drug-controlled gene therapies.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bryant et al. created adaptamers, 120 bp RNA sequences which act as regulatory elements of mRNAs so that translation only occurs in the presence of a small molecule inducer (tetracycline or doxycycline). They work by recruiting endogenous adenosine deaminases to edit out a stop codon only when the inducer stabilizes a stem loop structure. A [\u2026]<\/p>\n","protected":false},"author":636,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-246890","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/246890","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/636"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=246890"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/246890\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=246890"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=246890"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=246890"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}