{"id":246872,"date":"2026-11-08T18:13:08","date_gmt":"2026-11-09T00:13:08","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/11\/distinct-endogenous-retroviruses-are-expressed-in-mutational-subtypes-of-clear-cell-renal-cell-carcinoma-and-are-linked-to-improved-clinical-outcomes"},"modified":"2026-11-08T18:13:08","modified_gmt":"2026-11-09T00:13:08","slug":"distinct-endogenous-retroviruses-are-expressed-in-mutational-subtypes-of-clear-cell-renal-cell-carcinoma-and-are-linked-to-improved-clinical-outcomes","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/11\/distinct-endogenous-retroviruses-are-expressed-in-mutational-subtypes-of-clear-cell-renal-cell-carcinoma-and-are-linked-to-improved-clinical-outcomes","title":{"rendered":"Distinct endogenous retroviruses are expressed in mutational subtypes of clear cell renal cell carcinoma and are linked to improved clinical outcomes"},"content":{"rendered":"\n<p>Meli et al. conduct a comprehensive characterization of transposable element expression in clear cell renal cell carcinoma (ccRCC) mutational subtypes. They identify two specific endogenous retroviruses that are upregulated in PBRM1-mutant ccRCC and whose expression may contribute to selective immune checkpoint blockade response in distinct clinical settings.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Meli et al. conduct a comprehensive characterization of transposable element expression in clear cell renal cell carcinoma (ccRCC) mutational subtypes. They identify two specific endogenous retroviruses that are upregulated in PBRM1-mutant ccRCC and whose expression may contribute to selective immune checkpoint blockade response in distinct clinical settings.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-246872","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/246872","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=246872"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/246872\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=246872"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=246872"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=246872"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}