{"id":246703,"date":"2026-11-06T02:24:56","date_gmt":"2026-11-06T08:24:56","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/11\/engineered-protein-that-cuts-alzheimers-linked-brain-deposits-opens-potential-therapeutic-avenue"},"modified":"2026-11-06T02:24:56","modified_gmt":"2026-11-06T08:24:56","slug":"engineered-protein-that-cuts-alzheimers-linked-brain-deposits-opens-potential-therapeutic-avenue","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/11\/engineered-protein-that-cuts-alzheimers-linked-brain-deposits-opens-potential-therapeutic-avenue","title":{"rendered":"Engineered protein that cuts Alzheimer\u2019s-linked brain deposits opens potential therapeutic avenue"},"content":{"rendered":"\n<p>A KAIST-led research team has found that a protein involved in gene regulation can suppress the harmful aggregation of amyloid-beta, a peptide associated with Alzheimer\u2019s disease. The approach also reduced the toxicity of protein aggregates that had already formed.<\/p>\n<p>In experiments using a mouse model of Alzheimer\u2019s disease, the treatment reduced protein accumulation in the brain and improved memory recognition, suggesting a possible route toward new therapeutics.<\/p>\n<p>The research team led by Professor Mi Hee Lim from the Department of Chemistry identified a new approach to controlling the aggregation and toxicity of amyloid-beta. The findings were <a href=\"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.77886\" target=\"_blank\">published<\/a> in Advanced Science.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A KAIST-led research team has found that a protein involved in gene regulation can suppress the harmful aggregation of amyloid-beta, a peptide associated with Alzheimer\u2019s disease. The approach also reduced the toxicity of protein aggregates that had already formed. In experiments using a mouse model of Alzheimer\u2019s disease, the treatment reduced protein accumulation in the [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-246703","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/246703","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=246703"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/246703\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=246703"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=246703"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=246703"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}