{"id":246662,"date":"2026-11-05T10:27:28","date_gmt":"2026-11-05T16:27:28","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/11\/alix-regulates-tumor-mediated-immunosuppression-by-controlling-egfr-activity-and-pd-l1-presentation"},"modified":"2026-11-05T10:27:28","modified_gmt":"2026-11-05T16:27:28","slug":"alix-regulates-tumor-mediated-immunosuppression-by-controlling-egfr-activity-and-pd-l1-presentation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/11\/alix-regulates-tumor-mediated-immunosuppression-by-controlling-egfr-activity-and-pd-l1-presentation","title":{"rendered":"ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation"},"content":{"rendered":"\n<p>(Cell Reports <i>24<\/i>, 630\u2013641; July 17, 2018) <\/p>\n<p>As published, blots showing the PD168393-sensitive, EGF-dependent phosphorylation of the CrkII-based Picchu-X biosensor in HCC1954 cells (Figure 1A) were inadvertently duplicated from an experiment showing the Mo-IPQA-sensitive, EGF-dependent phosphorylation of the CrkII-based Picchu-X biosensor in HCC1954 cells. This latter experiment was published as Figure 1B in PMID: <a id=\"intref0010\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28166195\/\" target=\"_blank\">28166195<\/a>.<\/p>\n<p>Mo-IPQA is a PD168393 derivative, and figures for both papers were prepared concurrently, leading to the inadvertent duplication.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>(Cell Reports 24, 630\u2013641; July 17, 2018) As published, blots showing the PD168393-sensitive, EGF-dependent phosphorylation of the CrkII-based Picchu-X biosensor in HCC1954 cells (Figure 1A) were inadvertently duplicated from an experiment showing the Mo-IPQA-sensitive, EGF-dependent phosphorylation of the CrkII-based Picchu-X biosensor in HCC1954 cells. This latter experiment was published as Figure 1B in PMID: 28166195. [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-246662","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/246662","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=246662"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/246662\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=246662"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=246662"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=246662"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}