{"id":246126,"date":"2026-10-29T06:13:25","date_gmt":"2026-10-29T11:13:25","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/10\/gram-negative-bacterial-resistance"},"modified":"2026-10-29T06:13:25","modified_gmt":"2026-10-29T11:13:25","slug":"gram-negative-bacterial-resistance","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/10\/gram-negative-bacterial-resistance","title":{"rendered":"Gram-Negative Bacterial Resistance"},"content":{"rendered":"\n<p>The rapid worldwide spread of antimicrobial resistance among gram-negative bacteria is driven by a complex interplay of human, environmental, and health care\u2013associated factors and accelerated by mobile genetic elements that facilitate the dissemination of resistance genes. Resistance in gram-negative bacteria arises primarily through reduced drug entry, active drug efflux, modification of antibiotic targets, and enzymatic drug inactivation, most notably through \u03b2-lactamase production. Clinically important resistant pathogens include extended-spectrum \u03b2-lactamase\u2013producing Enterobacterales, carbapenem-resistant Enterobacterales, <i>Pseudomonas aeruginosa<\/i> with difficult-to-treat resistance, and carbapenem-resistant Acinetobacter baumannii.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The rapid worldwide spread of antimicrobial resistance among gram-negative bacteria is driven by a complex interplay of human, environmental, and health care\u2013associated factors and accelerated by mobile genetic elements that facilitate the dissemination of resistance genes. Resistance in gram-negative bacteria arises primarily through reduced drug entry, active drug efflux, modification of antibiotic targets, and enzymatic [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,1495],"tags":[],"class_list":["post-246126","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/246126","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=246126"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/246126\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=246126"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=246126"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=246126"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}