{"id":246102,"date":"2026-10-29T05:57:28","date_gmt":"2026-10-29T10:57:28","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/10\/mutated-immune-cells-raise-red-flags-in-lupus"},"modified":"2026-10-29T05:57:28","modified_gmt":"2026-10-29T10:57:28","slug":"mutated-immune-cells-raise-red-flags-in-lupus","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/10\/mutated-immune-cells-raise-red-flags-in-lupus","title":{"rendered":"Mutated immune cells raise red flags in lupus"},"content":{"rendered":"\n<p>Scientists at La Jolla Institute for Immunology (LJI) and the University of Washington (UW) have discovered that patients with lupus have unusual mutations that may turn their bodies into battlegrounds.<\/p>\n<p>These mutations are widespread in immune cells called neutrophils. Other immune cells see the mutated neutrophils as a threat\u2014and they try to fight back. This internal battle may contribute to the development of painful inflammation, debilitating joint pain and other serious lupus symptoms throughout the body.<\/p>\n<p>\u201cThis may get to the very crux of the disease pathogenesis,\u201d says LJI professor Stephen Schoenberger, Ph.D., who co-led the new <i>Nature<\/i> <a href=\"https:\/\/www.nature.com\/articles\/s41586-026-11219-7\" target=\"_blank\">study<\/a> with UW School of Medicine professor Tomas Mustelin, M.D., Ph.D.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists at La Jolla Institute for Immunology (LJI) and the University of Washington (UW) have discovered that patients with lupus have unusual mutations that may turn their bodies into battlegrounds. These mutations are widespread in immune cells called neutrophils. Other immune cells see the mutated neutrophils as a threat\u2014and they try to fight back. This [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-246102","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/246102","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=246102"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/246102\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=246102"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=246102"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=246102"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}