{"id":245435,"date":"2026-10-15T01:51:07","date_gmt":"2026-10-15T06:51:07","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/10\/common-leukemia-mutation-derails-protein-positioning-during-cell-division-study-reveals"},"modified":"2026-10-15T01:51:07","modified_gmt":"2026-10-15T06:51:07","slug":"common-leukemia-mutation-derails-protein-positioning-during-cell-division-study-reveals","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/10\/common-leukemia-mutation-derails-protein-positioning-during-cell-division-study-reveals","title":{"rendered":"Common leukemia mutation derails protein positioning during cell division, study reveals"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/common-leukemia-mutation-derails-protein-positioning-during-cell-division-study-reveals2.jpg\"><\/a><\/p>\n<p>Experts from the University of Nottingham have discovered how a common genetic mutation disrupts the positioning of a key protein during cell division, revealing a new mechanism behind acute myeloid leukemia and a potential avenue for future treatment.<\/p>\n<p>Acute myeloid leukemia (AML) is an aggressive blood cancer that disrupts the production of healthy blood cells. Around one-third of patients carry a mutation in a gene called NPM1, which causes its protein to accumulate in the wrong part of the cell and plays a key role in driving the disease.<\/p>\n<p>Until now, research has largely focused on how the mutated protein moves between the cell\u2019s nucleus and the surrounding cytoplasm. But a new study, led by Dr. Daniel Booth and Dr. Claire Seedhouse at the University of Nottingham\u2019s School of Medicine, reveals that what happens during cell division itself is also critical.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Experts from the University of Nottingham have discovered how a common genetic mutation disrupts the positioning of a key protein during cell division, revealing a new mechanism behind acute myeloid leukemia and a potential avenue for future treatment. Acute myeloid leukemia (AML) is an aggressive blood cancer that disrupts the production of healthy blood cells. [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-245435","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/245435","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=245435"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/245435\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=245435"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=245435"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=245435"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}