{"id":245365,"date":"2026-10-14T02:13:22","date_gmt":"2026-10-14T07:13:22","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/10\/cannabinoid-modulation-of-central-amygdala-population-dynamics-during-threat-investigation"},"modified":"2026-10-14T02:13:22","modified_gmt":"2026-10-14T07:13:22","slug":"cannabinoid-modulation-of-central-amygdala-population-dynamics-during-threat-investigation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/10\/cannabinoid-modulation-of-central-amygdala-population-dynamics-during-threat-investigation","title":{"rendered":"Cannabinoid modulation of central amygdala population dynamics during threat investigation"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/cannabinoid-modulation-of-central-amygdala-population-dynamics-during-threat-investigation2.jpg\"><\/a><\/p>\n<p>Neural mechanisms underlying cannabinoids\u2019 anxiogenic effects are not fully understood. Here authors show that cannabinoids dose-dependently increased spontaneous activity of central amygdala (CeA) neurons expressing somatostatin (SOM), altered CeA activity patterns during threat processing, and enhanced defensive behavior. Ex vivo studies in brain slices further showed that cannabinoids reduce inhibitory input from neighboring neurons, releasing a \u201cbrake\u201d on SOM activity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Neural mechanisms underlying cannabinoids\u2019 anxiogenic effects are not fully understood. Here authors show that cannabinoids dose-dependently increased spontaneous activity of central amygdala (CeA) neurons expressing somatostatin (SOM), altered CeA activity patterns during threat processing, and enhanced defensive behavior. Ex vivo studies in brain slices further showed that cannabinoids reduce inhibitory input from neighboring neurons, releasing [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-245365","post","type-post","status-publish","format-standard","hentry","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/245365","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=245365"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/245365\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=245365"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=245365"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=245365"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}