{"id":245299,"date":"2026-10-13T09:19:50","date_gmt":"2026-10-13T14:19:50","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/10\/tumor-derived-ilp8-and-upd3-contribute-to-intestinal-progenitor-cells-depletion-during-cachexia-in-drosophila-larvae"},"modified":"2026-10-13T09:19:50","modified_gmt":"2026-10-13T14:19:50","slug":"tumor-derived-ilp8-and-upd3-contribute-to-intestinal-progenitor-cells-depletion-during-cachexia-in-drosophila-larvae","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/10\/tumor-derived-ilp8-and-upd3-contribute-to-intestinal-progenitor-cells-depletion-during-cachexia-in-drosophila-larvae","title":{"rendered":"Tumor-derived Ilp8 and Upd3 contribute to intestinal progenitor cells depletion during cachexia in Drosophila larvae"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/tumor-derived-ilp8-and-upd3-contribute-to-intestinal-progenitor-cells-depletion-during-cachexia-in-drosophila-larvae2.jpg\"><\/a><\/p>\n<p>Falconi et al. show that neoplastic tumors in <i>Drosophila<\/i> wing discs trigger cachexia-like distant organ wasting, and alter larval midgut development by depleting adult midgut precursors and inducing premature differentiation of peripheral niche cells. These early defects define a previously unrecognized paraneoplastic phenotype controlled by tumor-derived Ilp8 and Upd3.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Falconi et al. show that neoplastic tumors in Drosophila wing discs trigger cachexia-like distant organ wasting, and alter larval midgut development by depleting adult midgut precursors and inducing premature differentiation of peripheral niche cells. These early defects define a previously unrecognized paraneoplastic phenotype controlled by tumor-derived Ilp8 and Upd3.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-245299","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/245299","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=245299"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/245299\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=245299"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=245299"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=245299"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}