{"id":245158,"date":"2026-10-10T01:06:20","date_gmt":"2026-10-10T06:06:20","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/10\/lab-grown-blood-vessels-reveal-roles-of-different-cells-in-rapid-aging-disease"},"modified":"2026-10-10T01:06:20","modified_gmt":"2026-10-10T06:06:20","slug":"lab-grown-blood-vessels-reveal-roles-of-different-cells-in-rapid-aging-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/10\/lab-grown-blood-vessels-reveal-roles-of-different-cells-in-rapid-aging-disease","title":{"rendered":"Lab-grown blood vessels reveal roles of different cells in rapid-aging disease"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/lab-grown-blood-vessels-reveal-roles-of-different-cells-in-rapid-aging-disease.jpg\"><\/a><\/p>\n<p>Biomedical engineers at Duke University have developed a three-layer model of human blood vessels that enables researchers to better understand how Hutchinson-Gilford progeria syndrome (HGPS), a rare genetic disorder that causes accelerated aging, affects the vascular system.<\/p>\n<p>By combining three major types of cells found in blood vessel walls, this new model allows researchers to more comprehensively study how certain cells are affected by HGPS and explore how they respond to new therapies. The work is <a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.aeh3785\" target=\"_blank\">published<\/a> in Science Advances.<\/p>\n<p>HGPS is an extremely rare, fatal disease that causes accelerated aging in children. The condition is triggered by a random gene mutation, and children with it typically die in their teens or early 20s, often from cardiovascular complications like heart disease or stroke. But these complications don\u2019t arise from the typical drivers of cardiovascular disease, such as high cholesterol and the subsequent formation of artery-clogging plaques. Instead, blood vessels in people with HGPS undergo major structural changes, including the loss of smooth muscle cells and increased stiffness.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Biomedical engineers at Duke University have developed a three-layer model of human blood vessels that enables researchers to better understand how Hutchinson-Gilford progeria syndrome (HGPS), a rare genetic disorder that causes accelerated aging, affects the vascular system. By combining three major types of cells found in blood vessel walls, this new model allows researchers to [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,269],"tags":[],"class_list":["post-245158","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/245158","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=245158"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/245158\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=245158"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=245158"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=245158"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}