{"id":245079,"date":"2026-10-09T02:02:35","date_gmt":"2026-10-09T07:02:35","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/10\/microglia-rescue-vulnerable-dopamine-neurons-in-parkinsons"},"modified":"2026-10-09T02:02:35","modified_gmt":"2026-10-09T07:02:35","slug":"microglia-rescue-vulnerable-dopamine-neurons-in-parkinsons","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/10\/microglia-rescue-vulnerable-dopamine-neurons-in-parkinsons","title":{"rendered":"Microglia Rescue Vulnerable Dopamine Neurons in Parkinson\u2019s"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/microglia-rescue-vulnerable-dopamine-neurons-in-parkinsons.jpg\"><\/a><\/p>\n<p>Summary: Researchers at the University of Oxford have discovered that human microglia can selectively prune away toxic alpha-synuclein aggregates from dopamine-producing neurons without destroying the host nerve cells. Utilizing co-cultures of human induced pluripotent stem cell (iPSC)-derived neurons and microglia, the team demonstrated that microglia employ \u201ctrogocytosis\u201d, a precise cellular nibbling mechanism, regulated by GPNMB, P2RY12, and CD22 signaling pathways, along with an IL-10 molecular brake. The findings identify a distinct, neuroprotective microglial subtype that shields neurons in Parkinson\u2019s disease.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: Researchers at the University of Oxford have discovered that human microglia can selectively prune away toxic alpha-synuclein aggregates from dopamine-producing neurons without destroying the host nerve cells. Utilizing co-cultures of human induced pluripotent stem cell (iPSC)-derived neurons and microglia, the team demonstrated that microglia employ \u201ctrogocytosis\u201d, a precise cellular nibbling mechanism, regulated by GPNMB, [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-245079","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/245079","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=245079"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/245079\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=245079"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=245079"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=245079"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}