{"id":244892,"date":"2026-10-04T01:04:09","date_gmt":"2026-10-04T06:04:09","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/10\/targeting-cdk2-could-boost-cancer-immunotherapy-response"},"modified":"2026-10-04T01:04:09","modified_gmt":"2026-10-04T06:04:09","slug":"targeting-cdk2-could-boost-cancer-immunotherapy-response","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/10\/targeting-cdk2-could-boost-cancer-immunotherapy-response","title":{"rendered":"Targeting CDK2 Could Boost Cancer Immunotherapy Response"},"content":{"rendered":"<p><\/p>\n<p><iframe loading=\"lazy\" allowfullscreen=\"true\" src=\"https:\/\/player.vimeo.com\/video\/1093770085?app_id=122963\" width=\"900\" height=\"506\" frameborder=\"0\" allow=\"autoplay; fullscreen; picture-in-picture; clipboard-write; encrypted-media; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" title=\"Making Medicine: Cancer Immunotherapies\"><\/iframe><\/p>\n<p>The study, <a href=\"https:\/\/us.cisionone.cision.com\/c\/eJwszE1OwzAQQOHT2DtHjmf8t_Cim54Asa0m9oRYtQkkaaGcHhWx_Z70SjIho3aS0-hDQI3RarkkxgheT6YYokDz6Em7EUE7Bm8pWFmToxgYs3ezz3AZMYZsA1prAwnUey18rZ-qU2287cphxhh9zkX161fD4RlkS8txfOwCTsKchTlP9RjaQ5gzvMzw-v0jO5dKauPGtLOqJf3B5R8EnAARtZZb6mtrj0vPZX1fb2-LQL30fVhou9NWBi43uR8bc39OJnTM3oHymEeFEUBNWbMKNmY_x8iFJ3lP5jcAAP__5oRXKQ\">published Sept. 2 in <em>Molecular Cell<\/em><\/a>, identifies a previously unrecognized role for CDK2 in shaping a tumor\u2019s interaction with the immune system. In mice, blocking CDK2 helped immunotherapy drugs known as immune checkpoint inhibitors eradicate colorectal and breast tumors, including a form of triple-negative breast cancer that did not respond to immunotherapy alone.<\/p>\n<p><a href=\"https:\/\/hms.harvard.edu\/news-events\/sign-email-communications\" title=\"Sign Up for Email Communications\">Get more HMS news<\/a><\/p>\n<p>\u201cCDK2 inhibitors are being tested in clinical trials now, primarily in forms of ovarian and breast cancer known to require CDK2 for cancer cell growth,\u201d said co-senior author <a href=\"https:\/\/connects.catalyst.harvard.edu\/Profiles\/display\/Person\/82335\">Peter Sicinski<\/a>, HMS professor of genetics at Dana-Farber. \u201cBut we\u2019ve found that CDK2 inhibitors can be used in a way we did not expect, to overcome resistance to immune checkpoint inhibitors.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The study, published Sept. 2 in Molecular Cell, identifies a previously unrecognized role for CDK2 in shaping a tumor\u2019s interaction with the immune system. In mice, blocking CDK2 helped immunotherapy drugs known as immune checkpoint inhibitors eradicate colorectal and breast tumors, including a form of triple-negative breast cancer that did not respond to immunotherapy alone. [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-244892","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/244892","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=244892"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/244892\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=244892"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=244892"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=244892"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}