{"id":244833,"date":"2026-10-02T17:10:57","date_gmt":"2026-10-02T22:10:57","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/10\/mitochondrial-carrier-slc25a34-links-clock-diet-and-temperature-control-of-adipocyte-lipid-cycling"},"modified":"2026-10-02T17:10:57","modified_gmt":"2026-10-02T22:10:57","slug":"mitochondrial-carrier-slc25a34-links-clock-diet-and-temperature-control-of-adipocyte-lipid-cycling","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/10\/mitochondrial-carrier-slc25a34-links-clock-diet-and-temperature-control-of-adipocyte-lipid-cycling","title":{"rendered":"Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/mitochondrial-carrier-slc25a34-links-clock-diet-and-temperature-control-of-adipocyte-lipid-cycling2.jpg\"><\/a><\/p>\n<p>An unexpected and potentially big finding:<\/p>\n<p>A single mitochondrial protein has an outsized role, acting as a central node, coordinating our circadian clock, temperature, dietary cues, sleep\/wake cycle to control brown fat metabolism.<\/p>\n<p>Brown\/beige fat burns energy to keep the body warm and is linked to metabolic health. Its activity follows a daily rhythm (high when you\u2019re awake, low during sleep), but it can also ramp up *suddenly* in response to cold weather or a fatty meal. How one system handles both scheduled and surprise demands was a mystery \u2014 until now.<\/p>\n<p>The answer: one mitochondrial protein, SLC25A34.<\/p>\n<p>The researchers found that three different signals \u2014 the circadian clock, diet, and temperature \u2014 all funnel through a single orphan mitochondrial transporter called SLC25A34.<\/p>\n<p>How it works:<\/p>\n<p>- During sleep: The circadian clock proteins REV-ERB\u03b1\/\u03b2 shut off SLC25A34 production.<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2026\/10\/mitochondrial-carrier-slc25a34-links-clock-diet-and-temperature-control-of-adipocyte-lipid-cycling\">Continue reading \u201cMitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling\u201d | &gt;<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>An unexpected and potentially big finding: A single mitochondrial protein has an outsized role, acting as a central node, coordinating our circadian clock, temperature, dietary cues, sleep\/wake cycle to control brown fat metabolism. Brown\/beige fat burns energy to keep the body warm and is linked to metabolic health. Its activity follows a daily rhythm (high [\u2026]<\/p>\n","protected":false},"author":709,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1495],"tags":[],"class_list":["post-244833","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/244833","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/709"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=244833"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/244833\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=244833"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=244833"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=244833"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}