{"id":244350,"date":"2026-09-21T21:52:02","date_gmt":"2026-09-22T02:52:02","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/09\/lipid-nanoparticles-for-mrna-delivery-in-brain-via-systemic-administration"},"modified":"2026-09-21T21:52:02","modified_gmt":"2026-09-22T02:52:02","slug":"lipid-nanoparticles-for-mrna-delivery-in-brain-via-systemic-administration","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/09\/lipid-nanoparticles-for-mrna-delivery-in-brain-via-systemic-administration","title":{"rendered":"Lipid nanoparticles for mRNA delivery in brain via systemic administration"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/lipid-nanoparticles-for-mrna-delivery-in-brain-via-systemic-administration2.jpg\"><\/a><\/p>\n<p>Cao et al. made lipid nanoparticles (LNPs) equipped with a small molecule ligand for blood-brain-barrier (BBB) 5-HT3 receptor and a cell penetrating peptide known as Tat. These LNPs crossed the BBB in mice more efficiently than control formulations.<\/p>\n<hr>\n<p>Peptide-modified lipid nanoparticles enable systemic IL-12 mRNA delivery for glioblastoma treatment.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cao et al. made lipid nanoparticles (LNPs) equipped with a small molecule ligand for blood-brain-barrier (BBB) 5-HT3 receptor and a cell penetrating peptide known as Tat. These LNPs crossed the BBB in mice more efficiently than control formulations. Peptide-modified lipid nanoparticles enable systemic IL-12 mRNA delivery for glioblastoma treatment.<\/p>\n","protected":false},"author":636,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,4,47],"tags":[],"class_list":["post-244350","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-nanotechnology","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/244350","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/636"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=244350"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/244350\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=244350"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=244350"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=244350"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}