{"id":244266,"date":"2026-09-19T21:03:17","date_gmt":"2026-09-20T02:03:17","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/09\/cd73-and-pd-l1-expression-in-who-grade-1-and-grade-2-meningiomas-an-exploratory-analysis-of-purinergic-and-immune-related-profiles"},"modified":"2026-09-19T21:03:17","modified_gmt":"2026-09-20T02:03:17","slug":"cd73-and-pd-l1-expression-in-who-grade-1-and-grade-2-meningiomas-an-exploratory-analysis-of-purinergic-and-immune-related-profiles","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/09\/cd73-and-pd-l1-expression-in-who-grade-1-and-grade-2-meningiomas-an-exploratory-analysis-of-purinergic-and-immune-related-profiles","title":{"rendered":"CD73 and PD-L1 expression in WHO grade 1 and grade 2 meningiomas: an exploratory analysis of purinergic and immune-related profiles"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/cd73-and-pd-l1-expression-in-who-grade-1-and-grade-2-meningiomas-an-exploratory-analysis-of-purinergic-and-immune-related-profiles2.jpg\"><\/a><\/p>\n<p>Meningiomas are the most common primary central nervous system tumors and exhibit heterogeneous biological behavior across WHO grades. Emerging evidence suggests that purinergic signaling and immune-related pathways may contribute to meningioma biology.<\/p>\n<p>This study evaluated the expression and activity of CD39\/ENTPD1 and CD73\/NT5E, the expression of PD-L1\/CD274, and the systemic inflammatory profile in patients undergoing surgical resection of meningiomas.<\/p>\n<p>Forty patients were included, with specific subgroups available for molecular, immunohistochemical, enzymatic, and cytokine analyses. Molecular comparisons were restricted to WHO grade 1 and grade 2 tumors. NT5E\/CD73 expression was higher in WHO grade 2 tumors at both mRNA and protein levels, whereas CD274\/PD-L1 expression was lower. Peripheral CD39\/CD73 enzymatic activity also differed between study groups, while plasma cytokines showed non-significant trends toward higher concentrations in patients with WHO grade 2 tumors.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Meningiomas are the most common primary central nervous system tumors and exhibit heterogeneous biological behavior across WHO grades. Emerging evidence suggests that purinergic signaling and immune-related pathways may contribute to meningioma biology. This study evaluated the expression and activity of CD39\/ENTPD1 and CD73\/NT5E, the expression of PD-L1\/CD274, and the systemic inflammatory profile in patients undergoing [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19],"tags":[],"class_list":["post-244266","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/244266","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=244266"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/244266\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=244266"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=244266"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=244266"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}