{"id":243514,"date":"2026-09-02T09:04:25","date_gmt":"2026-09-02T14:04:25","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/09\/radiological-response-of-primary-central-nervous-system-lymphoma-after-corticosteroid-therapy-and-its-predictive-value-on-overall-survival-a-multicenter-study"},"modified":"2026-09-02T09:04:25","modified_gmt":"2026-09-02T14:04:25","slug":"radiological-response-of-primary-central-nervous-system-lymphoma-after-corticosteroid-therapy-and-its-predictive-value-on-overall-survival-a-multicenter-study","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/09\/radiological-response-of-primary-central-nervous-system-lymphoma-after-corticosteroid-therapy-and-its-predictive-value-on-overall-survival-a-multicenter-study","title":{"rendered":"Radiological response of primary central nervous system lymphoma after corticosteroid therapy and its predictive value on overall survival: a multicenter study"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/radiological-response-of-primary-central-nervous-system-lymphoma-after-corticosteroid-therapy-and-its-predictive-value-on-overall-survival-a-multicenter-study2.jpg\"><\/a><\/p>\n<p>Primary Large-B-Cell Lymphoma of the CNS (PCNS-LBCL) is a rare, aggressive tumor often sensitive to corticosteroid therapy (CST). This multicenter study investigated the spectrum of radiological responses to routine CST and evaluated its impact on patient prognosis.<\/p>\n<p>The researchers utilized a prospective cohort of 18 patients for volumetric MRI analysis and a combined prospective-retrospective cohort of 31 patients for 2D tumor analysis. Patients received CST post-biopsy, with follow-up MRIs performed on the seventh day (median) after surgery. The study correlated radiological responses with CST dosage, LDH levels, and overall survival (OS) using Kaplan-Meier and Firth-corrected Cox regression.<\/p>\n<p>In the prospective cohort, 83.3% of tumors regressed with a median regression of 40%, while 16.7% progressed despite CST resulting in a median progression of 46%. These changes were not dose-dependent, but there were indications of a correlation with LDH levels. Patients showing regression had a median OS of 31.4 months, compared to 3.9 months for tumors progressing during CST (<i>p<\/i> = 0.015). Firth-corrected Cox regression showed, despite the small sample size, that radiological response (<i>p<\/i> = 0.02) could be a promising prognostic factor in a model including age, type of therapy and Karnofsky performance status.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Primary Large-B-Cell Lymphoma of the CNS (PCNS-LBCL) is a rare, aggressive tumor often sensitive to corticosteroid therapy (CST). This multicenter study investigated the spectrum of radiological responses to routine CST and evaluated its impact on patient prognosis. The researchers utilized a prospective cohort of 18 patients for volumetric MRI analysis and a combined prospective-retrospective cohort [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-243514","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/243514","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=243514"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/243514\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=243514"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=243514"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=243514"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}