{"id":243386,"date":"2026-08-30T02:04:58","date_gmt":"2026-08-30T07:04:58","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/08\/depression-may-leave-a-physical-mark-on-the-aging-brain"},"modified":"2026-08-30T02:04:58","modified_gmt":"2026-08-30T07:04:58","slug":"depression-may-leave-a-physical-mark-on-the-aging-brain","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/08\/depression-may-leave-a-physical-mark-on-the-aging-brain","title":{"rendered":"Depression May Leave a Physical Mark on the Aging Brain"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/depression-may-leave-a-physical-mark-on-the-aging-brain.jpg\"><\/a><\/p>\n<p>Researchers analyzed MRI scans from 2,009 cognitively healthy older adults. Depression was associated with reduced volume in the hippocampal CA23DG subfield, independent of amyloid, tau, and genetic Alzheimer\u2019s risk factors.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers analyzed MRI scans from 2,009 cognitively healthy older adults. Depression was associated with reduced volume in the hippocampal CA23DG subfield, independent of amyloid, tau, and genetic Alzheimer\u2019s risk factors.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,269,47],"tags":[],"class_list":["post-243386","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/243386","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=243386"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/243386\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=243386"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=243386"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=243386"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}