{"id":243348,"date":"2026-08-28T21:25:06","date_gmt":"2026-08-29T02:25:06","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/08\/vegfr2-inhibition-potentiates-stingmediated-antitumor-immunity"},"modified":"2026-08-28T21:25:06","modified_gmt":"2026-08-29T02:25:06","slug":"vegfr2-inhibition-potentiates-stingmediated-antitumor-immunity","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/08\/vegfr2-inhibition-potentiates-stingmediated-antitumor-immunity","title":{"rendered":"VEGFR2 inhibition potentiates STINGmediated antitumor immunity"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/vegfr2-inhibition-potentiates-stingmediated-antitumor-immunity2.jpg\"><\/a><\/p>\n<p>Han et al. identify VEGFR2 as a suppressor of cGAMP-STING signaling. Upon cGAMP stimulation, VEGFR2 is phosphorylated and suppresses STING activation via activating and recruiting AKT1. The VEGFR2 inhibitor Ki8751 relieves this repression and activates NF-\u03baB signaling, further amplifying STING responses and the antitumor effect.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Han et al. identify VEGFR2 as a suppressor of cGAMP-STING signaling. Upon cGAMP stimulation, VEGFR2 is phosphorylated and suppresses STING activation via activating and recruiting AKT1. The VEGFR2 inhibitor Ki8751 relieves this repression and activates NF-\u03baB signaling, further amplifying STING responses and the antitumor effect.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-243348","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/243348","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=243348"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/243348\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=243348"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=243348"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=243348"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}