{"id":243343,"date":"2026-08-28T21:16:10","date_gmt":"2026-08-29T02:16:10","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/08\/immunosuppressive-myeloid-cells-induce-mesenchymallike-breast-cancer-stem-cells-by-a-membranebound-tgf%ce%b21dependent-mechanism"},"modified":"2026-08-28T21:16:10","modified_gmt":"2026-08-29T02:16:10","slug":"immunosuppressive-myeloid-cells-induce-mesenchymallike-breast-cancer-stem-cells-by-a-membranebound-tgf%ce%b21dependent-mechanism","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/08\/immunosuppressive-myeloid-cells-induce-mesenchymallike-breast-cancer-stem-cells-by-a-membranebound-tgf%ce%b21dependent-mechanism","title":{"rendered":"Immunosuppressive myeloid cells induce mesenchymallike breast cancer stem cells by a membranebound TGF\u03b21dependent mechanism"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/immunosuppressive-myeloid-cells-induce-mesenchymallike-breast-cancer-stem-cells-by-a-membranebound-tgfceb21dependent-mechanism2.jpg\"><\/a><\/p>\n<p>Boyer, Blaye et al. show that CD52-expressing immunosuppressive myeloid cells can shape breast tumor plasticity beyond immune evasion. They show that this myeloid subset delivers membrane-bound TGF-\u03b21 via cell contact to generate mesenchymal-like cancer stem cells in luminal breast cancer, and TGF-\u03b2 blockade prevents this stemness program.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Boyer, Blaye et al. show that CD52-expressing immunosuppressive myeloid cells can shape breast tumor plasticity beyond immune evasion. They show that this myeloid subset delivers membrane-bound TGF-\u03b21 via cell contact to generate mesenchymal-like cancer stem cells in luminal breast cancer, and TGF-\u03b2 blockade prevents this stemness program.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-243343","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/243343","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=243343"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/243343\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=243343"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=243343"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=243343"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}