{"id":242908,"date":"2026-08-19T21:05:42","date_gmt":"2026-08-20T02:05:42","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/08\/tunable-gene-control-via-rna-splicing-with-a-clinically-approved-small-molecule"},"modified":"2026-08-19T21:05:42","modified_gmt":"2026-08-20T02:05:42","slug":"tunable-gene-control-via-rna-splicing-with-a-clinically-approved-small-molecule","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/08\/tunable-gene-control-via-rna-splicing-with-a-clinically-approved-small-molecule","title":{"rendered":"Tunable gene control via RNA splicing with a clinically approved small molecule"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/tunable-gene-control-via-rna-splicing-with-a-clinically-approved-small-molecule.jpg\"><\/a><\/p>\n<p><i>et al.<\/i> developed a DNA sequence module which enables splicing-mediated control of gene expression via an inducer which is already an FDA-approved medicine. An extremely useful advance for gene therapy since it allows activation of therapeutic genes only when we want them to turn on. I expect this kind of tool will be used heavily by the biomedical industry in coming years.<\/p>\n<hr>\n<p>Precise transgene regulation is crucial for the safety and efficacy of next-generation therapies. Here, authors develop RisdiON, a compact gene switch controlled by the approved oral drug risdiplam, showing this system allows for tunable, reversible regulation across diverse applications in vitro and in vivo.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>et al. developed a DNA sequence module which enables splicing-mediated control of gene expression via an inducer which is already an FDA-approved medicine. An extremely useful advance for gene therapy since it allows activation of therapeutic genes only when we want them to turn on. I expect this kind of tool will be used heavily [\u2026]<\/p>\n","protected":false},"author":636,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-242908","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/242908","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/636"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=242908"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/242908\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=242908"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=242908"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=242908"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}