{"id":242905,"date":"2026-08-19T21:02:28","date_gmt":"2026-08-20T02:02:28","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/08\/a-lactate%ce%b1ketoglutarate-metabolic-circuit-in-tumorinfiltrating-regulatory-t-cells-accelerates-tumor-progression-by-inducing-nk-cell-senescence-cancer"},"modified":"2026-08-19T21:02:28","modified_gmt":"2026-08-20T02:02:28","slug":"a-lactate%ce%b1ketoglutarate-metabolic-circuit-in-tumorinfiltrating-regulatory-t-cells-accelerates-tumor-progression-by-inducing-nk-cell-senescence-cancer","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/08\/a-lactate%ce%b1ketoglutarate-metabolic-circuit-in-tumorinfiltrating-regulatory-t-cells-accelerates-tumor-progression-by-inducing-nk-cell-senescence-cancer","title":{"rendered":"A lactate\u03b1ketoglutarate metabolic circuit in tumorinfiltrating regulatory T cells accelerates tumor progression by inducing NK cell senescence Cancer"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/a-lactateceb1ketoglutarate-metabolic-circuit-in-tumorinfiltrating-regulatory-t-cells-accelerates-tumor-progression-by-inducing-nk-cell-senescence-cancer.jpg\"><\/a><\/p>\n<p>Shi et al show that a lactate\u2013\u03b1-ketoglutarate metabolic circuit in tumor-infiltrating regulatory T cells promotes WNT2-mediated senescence-like features in natural killer cells and disrupting this axis hinders tumor progression.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Shi et al show that a lactate\u2013\u03b1-ketoglutarate metabolic circuit in tumor-infiltrating regulatory T cells promotes WNT2-mediated senescence-like features in natural killer cells and disrupting this axis hinders tumor progression.<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-242905","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/242905","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=242905"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/242905\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=242905"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=242905"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=242905"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}