{"id":242674,"date":"2026-08-14T01:02:21","date_gmt":"2026-08-14T06:02:21","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/08\/study-reveals-new-role-for-tau-a-top-target-for-alzheimers-drug-development"},"modified":"2026-08-14T01:02:21","modified_gmt":"2026-08-14T06:02:21","slug":"study-reveals-new-role-for-tau-a-top-target-for-alzheimers-drug-development","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/08\/study-reveals-new-role-for-tau-a-top-target-for-alzheimers-drug-development","title":{"rendered":"Study reveals new role for tau, a top target for Alzheimer\u2019s drug development"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/study-reveals-new-role-for-tau-a-top-target-for-alzheimers-drug-development.jpg\"><\/a><\/p>\n<p>In the race for new ways to treat Alzheimer\u2019s and other devastating neurologic diseases, the protein tau has become a tantalizing target for drug developers. A new study lends support to those efforts by describing a previously unknown role that tau plays in neurodegeneration \u2014 and suggesting a novel way researchers might block the protein\u2019s activity.<\/p>\n<p>A team led by Stanford scientists found that tau can gum up the works of a cell\u2019s mitochondria, its energy-producing powerhouse. The protein sends electrons flowing in the opposite direction of their usual microscopic relay race, a reversal that generates reactive oxygen species, cellular stress, and inflammation. Scientists found that blocking this phenomenon, known as reverse electron transport, reversed many of the harmful effects and improved learning and memory in flies and mice.<\/p>\n<p>Whether the same will hold true in people is for now unclear, though an analysis of human cells grown in the lab and patient brain tissue suggests blocking the retrograde flow of electrons could make neurons healthier. Two of the study\u2019s authors have started a biotech startup to put this idea to the test.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In the race for new ways to treat Alzheimer\u2019s and other devastating neurologic diseases, the protein tau has become a tantalizing target for drug developers. A new study lends support to those efforts by describing a previously unknown role that tau plays in neurodegeneration \u2014 and suggesting a novel way researchers might block the protein\u2019s [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-242674","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/242674","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=242674"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/242674\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=242674"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=242674"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=242674"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}