{"id":242671,"date":"2026-08-13T21:03:56","date_gmt":"2026-08-14T02:03:56","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/08\/crispr-roadblocks-scientists-identify-genes-blocking-gene-therapy-success"},"modified":"2026-08-13T21:03:56","modified_gmt":"2026-08-14T02:03:56","slug":"crispr-roadblocks-scientists-identify-genes-blocking-gene-therapy-success","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/08\/crispr-roadblocks-scientists-identify-genes-blocking-gene-therapy-success","title":{"rendered":"CRISPR roadblocks: Scientists identify genes blocking gene therapy success"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/crispr-roadblocks-scientists-identify-genes-blocking-gene-therapy-success.jpg\"><\/a><\/p>\n<p>Like a delivery driver navigating crowded city streets, a gene-therapy-toting lipid nanoparticle faces a gauntlet of potential detours on its journey toward a cell\u2019s nucleus. First, there\u2019s entering the cell\u2019s plasma membrane; then navigating around organelles like the Golgi apparatus, mitochondria and endoplasmic reticulum\u2014all destinations that can errantly absorb the particle\u2019s payload, rendering it ineffective at best or harmful at worst. And that\u2019s all before the particle even enters the nucleus and successfully makes a genetic change.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Like a delivery driver navigating crowded city streets, a gene-therapy-toting lipid nanoparticle faces a gauntlet of potential detours on its journey toward a cell\u2019s nucleus. First, there\u2019s entering the cell\u2019s plasma membrane; then navigating around organelles like the Golgi apparatus, mitochondria and endoplasmic reticulum\u2014all destinations that can errantly absorb the particle\u2019s payload, rendering it ineffective [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,4],"tags":[],"class_list":["post-242671","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-nanotechnology"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/242671","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=242671"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/242671\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=242671"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=242671"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=242671"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}