{"id":242506,"date":"2026-08-11T01:07:13","date_gmt":"2026-08-11T06:07:13","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/08\/coordinating-the-development-of-heart-muscle-and-vasculature"},"modified":"2026-08-11T01:07:13","modified_gmt":"2026-08-11T06:07:13","slug":"coordinating-the-development-of-heart-muscle-and-vasculature","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/08\/coordinating-the-development-of-heart-muscle-and-vasculature","title":{"rendered":"Coordinating the development of heart muscle and vasculature"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/coordinating-the-development-of-heart-muscle-and-vasculature2.jpg\"><\/a><\/p>\n<p>During development, regional dips in oxygen levels serve as a signal that triggers the coordinated growth of heart muscle and coronary vessels, according to a new study. The findings, published in the <i>Proceedings of the National Academy of Sciences,<\/i> could point toward innovative approaches for treating cardiovascular conditions that lead to heart failure.<\/p>\n<p>\u201cThe signaling pathways that direct the development of this remarkable organ are also affected in pathological conditions,\u201d said the senior author. \u201cInterventions that target these signals or the cells that produce them could potentially change the trajectory of disease or slow its progression.\u201d<\/p>\n<p>One of the biggest mysteries was: what drives their growth\u2014and how is that expansion synchronized with that of the muscle tissue they serve? \u201cInitially we thought that there would be direct crosstalk between the two,\u201d the author said. Either the muscle secretes signals that attract developing vessels\u2014or the vessels produce signals that promote muscle growth.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>During development, regional dips in oxygen levels serve as a signal that triggers the coordinated growth of heart muscle and coronary vessels, according to a new study. The findings, published in the Proceedings of the National Academy of Sciences, could point toward innovative approaches for treating cardiovascular conditions that lead to heart failure. \u201cThe signaling [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1522],"tags":[],"class_list":["post-242506","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-innovation"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/242506","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=242506"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/242506\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=242506"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=242506"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=242506"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}