{"id":242174,"date":"2026-08-04T01:37:53","date_gmt":"2026-08-04T06:37:53","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/08\/the-cterminal-region-of-tent5-proteins-drives-erassociated-mrna-polyadenylation-via-fndc3-interaction"},"modified":"2026-08-04T01:37:53","modified_gmt":"2026-08-04T06:37:53","slug":"the-cterminal-region-of-tent5-proteins-drives-erassociated-mrna-polyadenylation-via-fndc3-interaction","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/08\/the-cterminal-region-of-tent5-proteins-drives-erassociated-mrna-polyadenylation-via-fndc3-interaction","title":{"rendered":"The Cterminal region of TENT5 proteins drives ERassociated mRNA polyadenylation via FNDC3 interaction"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/the-cterminal-region-of-tent5-proteins-drives-erassociated-mrna-polyadenylation-via-fndc3-interaction.jpg\"><\/a><\/p>\n<p>Viviani et al. identify the molecular determinants that recruit TENT5 poly(A) polymerases to the endoplasmic reticulum. A divergent C-terminal region mediates interaction with FNDC3 proteins, enabling ER localization and broad stabilization of transcripts encoding secretory pathway components. This spatial mechanism explains functional divergence among TENT5 paralogs.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Viviani et al. identify the molecular determinants that recruit TENT5 poly(A) polymerases to the endoplasmic reticulum. A divergent C-terminal region mediates interaction with FNDC3 proteins, enabling ER localization and broad stabilization of transcripts encoding secretory pathway components. This spatial mechanism explains functional divergence among TENT5 paralogs.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-242174","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/242174","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=242174"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/242174\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=242174"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=242174"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=242174"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}