{"id":242067,"date":"2026-08-02T08:31:16","date_gmt":"2026-08-02T13:31:16","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/08\/aging-restricts-maturation-of-cxcl13-t-follicular-helper-cells-in-human-immunity"},"modified":"2026-08-02T08:31:16","modified_gmt":"2026-08-02T13:31:16","slug":"aging-restricts-maturation-of-cxcl13-t-follicular-helper-cells-in-human-immunity","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/08\/aging-restricts-maturation-of-cxcl13-t-follicular-helper-cells-in-human-immunity","title":{"rendered":"Aging restricts maturation of CXCL13+ T follicular helper cells in human immunity"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/aging-restricts-maturation-of-cxcl13-t-follicular-helper-cells-in-human-immunity.jpg\"><\/a><\/p>\n<p>Bracey et al. show that impaired antibody responses with age are primarily driven by defective T follicular helper cell maturation rather than intrinsic B cell dysfunction. They identify loss of human-specific <i>CXCL13 <\/i>+ T follicular helper cells and reduced BACH2 and SOX4 as hallmarks of aging-associated humoral immune dysfunction.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bracey et al. show that impaired antibody responses with age are primarily driven by defective T follicular helper cell maturation rather than intrinsic B cell dysfunction. They identify loss of human-specific CXCL13 + T follicular helper cells and reduced BACH2 and SOX4 as hallmarks of aging-associated humoral immune dysfunction.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[269],"tags":[],"class_list":["post-242067","post","type-post","status-publish","format-standard","hentry","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/242067","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=242067"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/242067\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=242067"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=242067"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=242067"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}