{"id":241840,"date":"2026-07-30T09:09:33","date_gmt":"2026-07-30T14:09:33","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/07\/gene-editing-tool-reduces-huntingtons-toxic-protein-fragments-and-symptoms-in-mice"},"modified":"2026-07-30T09:09:33","modified_gmt":"2026-07-30T14:09:33","slug":"gene-editing-tool-reduces-huntingtons-toxic-protein-fragments-and-symptoms-in-mice","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/07\/gene-editing-tool-reduces-huntingtons-toxic-protein-fragments-and-symptoms-in-mice","title":{"rendered":"Gene editing tool reduces Huntington\u2019s toxic protein fragments and symptoms in mice"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/gene-editing-tool-reduces-huntingtons-toxic-protein-fragments-and-symptoms-in-mice.jpg\"><\/a><\/p>\n<p>A gene-editing tool designed to precisely rewrite the gene that causes Huntington\u2019s disease reduced toxic protein fragments and symptoms associated with the disease in mice, researchers at the University of Illinois Urbana-Champaign report.<\/p>\n<p>While other gene-based treatments have focused on turning the gene off, the Illinois team took a different approach. The researchers designed a base-editing tool to alter a specific point in the huntingtin gene so the cell\u2019s machinery would skip over a small section prone to generating toxic fragments while preserving enough huntingtin protein to support its normal functions.<\/p>\n<p>Led by Pablo Perez-Pinera and Thomas Gaj, professors of bioengineering at the U. of I., the researchers <a href=\"https:\/\/www.nature.com\/articles\/s41551-026-01747-y\" target=\"_blank\">published<\/a> their findings in the journal Nature Biomedical Engineering.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A gene-editing tool designed to precisely rewrite the gene that causes Huntington\u2019s disease reduced toxic protein fragments and symptoms associated with the disease in mice, researchers at the University of Illinois Urbana-Champaign report. While other gene-based treatments have focused on turning the gene off, the Illinois team took a different approach. The researchers designed a [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,412],"tags":[],"class_list":["post-241840","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241840","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=241840"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241840\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=241840"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=241840"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=241840"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}