{"id":241826,"date":"2026-07-30T04:09:37","date_gmt":"2026-07-30T09:09:37","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/07\/the-calcium-pump-atp2b1-pmca1-regulates-cns-vascular-development-by-facilitating-norrin-frizzled4-signaling"},"modified":"2026-07-30T04:09:37","modified_gmt":"2026-07-30T09:09:37","slug":"the-calcium-pump-atp2b1-pmca1-regulates-cns-vascular-development-by-facilitating-norrin-frizzled4-signaling","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/07\/the-calcium-pump-atp2b1-pmca1-regulates-cns-vascular-development-by-facilitating-norrin-frizzled4-signaling","title":{"rendered":"The calcium pump ATP2B1\/PMCA1 regulates CNS vascular development by facilitating Norrin Frizzled4 signaling"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/the-calcium-pump-atp2b1-pmca1-regulates-cns-vascular-development-by-facilitating-norrin-frizzled4-signaling2.jpg\"><\/a><\/p>\n<p>Jo et al. identify the plasma membrane Ca2+\u2212pump ATP2B1\/PMCA1 as a regulator of endothelial Norrin\/Frizzled4 and Wnt signaling in the CNS vasculature. Loss of ATP2B1 elevates intracellular Ca2+ and activates NFAT, suppressing \u03b2-catenin signaling and linking Ca2+ homeostasis to angiogenesis and blood-brain barrier integrity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Jo et al. identify the plasma membrane Ca2+\u2212pump ATP2B1\/PMCA1 as a regulator of endothelial Norrin\/Frizzled4 and Wnt signaling in the CNS vasculature. Loss of ATP2B1 elevates intracellular Ca2+ and activates NFAT, suppressing \u03b2-catenin signaling and linking Ca2+ homeostasis to angiogenesis and blood-brain barrier integrity.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-241826","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241826","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=241826"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241826\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=241826"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=241826"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=241826"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}