{"id":241799,"date":"2026-07-29T21:20:37","date_gmt":"2026-07-30T02:20:37","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/07\/nrf2mediated-inhibition-of-alveolar-macrophage-mhc-ii-expression-during-mycobacterium-tuberculosis-infection"},"modified":"2026-07-29T21:20:37","modified_gmt":"2026-07-30T02:20:37","slug":"nrf2mediated-inhibition-of-alveolar-macrophage-mhc-ii-expression-during-mycobacterium-tuberculosis-infection","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/07\/nrf2mediated-inhibition-of-alveolar-macrophage-mhc-ii-expression-during-mycobacterium-tuberculosis-infection","title":{"rendered":"NRF2mediated inhibition of alveolar macrophage MHC II expression during Mycobacterium tuberculosis infection"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/nrf2mediated-inhibition-of-alveolar-macrophage-mhc-ii-expression-during-mycobacterium-tuberculosis-infection2.jpg\"><\/a><\/p>\n<p>Pham et al. show that, during <i>Mycobacterium tuberculosis<\/i> infection, NRF2 activation in alveolar macrophages inhibits MHC II but not MHC I, leading to dampening of antigen presentation and CD4+ T cell activation. Although NRF2 promotes a cell-protective program, it unexpectedly impairs innate-adaptive crosstalk and host immunity in the lung.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pham et al. show that, during Mycobacterium tuberculosis infection, NRF2 activation in alveolar macrophages inhibits MHC II but not MHC I, leading to dampening of antigen presentation and CD4+ T cell activation. Although NRF2 promotes a cell-protective program, it unexpectedly impairs innate-adaptive crosstalk and host immunity in the lung.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-241799","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241799","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=241799"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241799\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=241799"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=241799"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=241799"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}