{"id":241765,"date":"2026-07-29T04:07:56","date_gmt":"2026-07-29T09:07:56","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/07\/helical-nanoparticles-trigger-cancer-alarms-and-deliver-gene-therapy"},"modified":"2026-07-29T04:07:56","modified_gmt":"2026-07-29T09:07:56","slug":"helical-nanoparticles-trigger-cancer-alarms-and-deliver-gene-therapy","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/07\/helical-nanoparticles-trigger-cancer-alarms-and-deliver-gene-therapy","title":{"rendered":"Helical nanoparticles trigger cancer alarms and deliver gene therapy"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/helical-nanoparticles-trigger-cancer-alarms-and-deliver-gene-therapy2.jpg\"><\/a><\/p>\n<p>Cancer cells survive by hiding from the immune system\u2019s surveillance. A KAIST research team has developed a new anticancer platform that makes cancer cells send out their own danger signals\u2014prompting immune cells to attack\u2014while simultaneously delivering gene therapy. The approach is expected to offer a new treatment strategy that combines cancer immunotherapy and gene therapy in a single nanoparticle.<\/p>\n<p>Immunogenic cell death (ICD) is a process in which dying cancer cells send danger signals to nearby immune cells, prompting them to attack. A polypeptide is a polymer made of a long chain of amino acids.<\/p>\n<p>A team led by Professor Yeu-Chun Kim from the KAIST Department of Chemical and Biomolecular Engineering developed a \u201chelical polypeptide nanoparticle\u201d platform that induces severe stress inside cancer cells to trigger immunogenic cell death while also delivering a range of gene therapeutics into the cells. The findings are <a href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961226003613\" target=\"_blank\">published<\/a> in the journal Biomaterials.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cancer cells survive by hiding from the immune system\u2019s surveillance. A KAIST research team has developed a new anticancer platform that makes cancer cells send out their own danger signals\u2014prompting immune cells to attack\u2014while simultaneously delivering gene therapy. The approach is expected to offer a new treatment strategy that combines cancer immunotherapy and gene therapy [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19,38,4],"tags":[],"class_list":["post-241765","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry","category-engineering","category-nanotechnology"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241765","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=241765"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241765\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=241765"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=241765"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=241765"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}