{"id":241608,"date":"2026-07-26T20:13:05","date_gmt":"2026-07-27T01:13:05","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/07\/lkb1-inactivation-elicits-an-nnmtmediated-methyl-sink-and-confers-dependence-on-prmt5-in-lung-cancer"},"modified":"2026-07-26T20:13:05","modified_gmt":"2026-07-27T01:13:05","slug":"lkb1-inactivation-elicits-an-nnmtmediated-methyl-sink-and-confers-dependence-on-prmt5-in-lung-cancer","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/07\/lkb1-inactivation-elicits-an-nnmtmediated-methyl-sink-and-confers-dependence-on-prmt5-in-lung-cancer","title":{"rendered":"LKB1 inactivation elicits an NNMTmediated methyl sink and confers dependence on PRMT5 in lung cancer"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/lkb1-inactivation-elicits-an-nnmtmediated-methyl-sink-and-confers-dependence-on-prmt5-in-lung-cancer2.jpg\"><\/a><\/p>\n<p>Mi et al. discover that LKB1 deficiency creates a hypomorphic PRMT5 state in lung cancer via NNMT-mediated \u201cmethyl sink.\u201d Targeting PRMT5 triggers senescence in LKB1-deficient cancer cells and confers vulnerability to senolytics such as Navitoclax, representing an effective combination cancer therapy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mi et al. discover that LKB1 deficiency creates a hypomorphic PRMT5 state in lung cancer via NNMT-mediated \u201cmethyl sink.\u201d Targeting PRMT5 triggers senescence in LKB1-deficient cancer cells and confers vulnerability to senolytics such as Navitoclax, representing an effective combination cancer therapy.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-241608","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241608","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=241608"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241608\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=241608"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=241608"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=241608"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}