{"id":241572,"date":"2026-07-26T04:02:31","date_gmt":"2026-07-26T09:02:31","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/07\/can-this-new-enzyme-reverse-aging"},"modified":"2026-07-26T04:02:31","modified_gmt":"2026-07-26T09:02:31","slug":"can-this-new-enzyme-reverse-aging","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/07\/can-this-new-enzyme-reverse-aging","title":{"rendered":"Can This New Enzyme Reverse Aging?"},"content":{"rendered":"<p><\/p>\n<p><iframe style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/fGjWaC5ZnPI?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>This is rather technical.<\/p>\n<hr>\n<p>Researchers at Revel Pharmaceuticals and Calico Life Sciences have engineered CMLase, an enzyme that removes carboxymethyl-lysine (CML) \u2014 a glycation product long considered permanent damage on our longest-lived proteins. In this video I explain the details behind this discovery and what it means for the aging field.<\/p>\n<p>Find me on Twitter \u2014 \/ eleanorsheekey.<br \/> official website \u2014 <a href=\"https:\/\/www.thesheekeyscienceshow.com\/\">https:\/\/www.thesheekeyscienceshow.com\/<\/a><\/p>\n<p>Support the channel.<br \/> through PayPal \u2014 <a href=\"https:\/\/paypal.me\/sheekeyscience?coun\">https:\/\/paypal.me\/sheekeyscience?coun<\/a>\u2026 through Patreon \u2014 <img class=\"\" alt=\"\"> \/ thesheekeyscienceshow TIMESTAMPS 0:00 \u2013 Intro: what CML is and why it seemed irreversible 2:25 \u2013 How they made the enzyme 6:20 \u2013 Human tissue data 7:40 \u2013 My thoughts and limitations Paper: Trabosh et al., Nature Communications, 2026 \u2014 <a href=\"https:\/\/doi.org\/10.1038\/s41467-026-75\">https:\/\/doi.org\/10.1038\/s41467-026-75<\/a>\u2026 note that The Sheekey Science Show is distinct from Eleanor Sheekey\u2019s teaching and research roles. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed. Icons in intro; \u201chttps:\/\/www.freepik.com\/free-photos-v\u2026\u201cBackground vector created by freepik \u2014 <a href=\"http:\/\/www.freepik.com\">www.freepik.com<\/a>.<br \/> through Patreon \u2014 \/ thesheekeyscienceshow.<\/p>\n<p>TIMESTAMPS<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2026\/07\/can-this-new-enzyme-reverse-aging\">Continue reading \u201cCan This New Enzyme Reverse Aging?\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This is rather technical. Researchers at Revel Pharmaceuticals and Calico Life Sciences have engineered CMLase, an enzyme that removes carboxymethyl-lysine (CML) \u2014 a glycation product long considered permanent damage on our longest-lived proteins. In this video I explain the details behind this discovery and what it means for the aging field. Find me on Twitter [\u2026]<\/p>\n","protected":false},"author":388,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,32,269],"tags":[],"class_list":["post-241572","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-education","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241572","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/388"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=241572"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241572\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=241572"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=241572"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=241572"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}