{"id":241560,"date":"2026-07-25T20:12:07","date_gmt":"2026-07-26T01:12:07","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/07\/neutrophilderived-itaconate-facilitates-tiered-pulmonary-inflammation-via-kdm5bassociated-epigenetic-remodeling-in-alveolar-macrophages"},"modified":"2026-07-25T20:12:07","modified_gmt":"2026-07-26T01:12:07","slug":"neutrophilderived-itaconate-facilitates-tiered-pulmonary-inflammation-via-kdm5bassociated-epigenetic-remodeling-in-alveolar-macrophages","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/07\/neutrophilderived-itaconate-facilitates-tiered-pulmonary-inflammation-via-kdm5bassociated-epigenetic-remodeling-in-alveolar-macrophages","title":{"rendered":"Neutrophilderived itaconate facilitates tiered pulmonary inflammation via Kdm5bassociated epigenetic remodeling in alveolar macrophages"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/neutrophilderived-itaconate-facilitates-tiered-pulmonary-inflammation-via-kdm5bassociated-epigenetic-remodeling-in-alveolar-macrophages2.jpg\"><\/a><\/p>\n<p>Lim et al. identify neutrophil-derived itaconate as a key environmental factor shaping tiered inflammatory responses in ALI. Itaconate metabolically promotes KDM5B-associated epigenetic activation of proinflammatory genes in alveolar macrophages, coordinating later-stage immune cell infiltration, including monocytes and T cells.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lim et al. identify neutrophil-derived itaconate as a key environmental factor shaping tiered inflammatory responses in ALI. Itaconate metabolically promotes KDM5B-associated epigenetic activation of proinflammatory genes in alveolar macrophages, coordinating later-stage immune cell infiltration, including monocytes and T cells.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[412],"tags":[],"class_list":["post-241560","post","type-post","status-publish","format-standard","hentry","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241560","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=241560"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241560\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=241560"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=241560"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=241560"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}