{"id":241523,"date":"2026-07-25T00:09:31","date_gmt":"2026-07-25T05:09:31","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/07\/derivation-of-a-datadriven-followup-protocol-for-resected-skull-base-meningiomas-a-bayesian-analysis-neurooncology"},"modified":"2026-07-25T00:09:31","modified_gmt":"2026-07-25T05:09:31","slug":"derivation-of-a-datadriven-followup-protocol-for-resected-skull-base-meningiomas-a-bayesian-analysis-neurooncology","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/07\/derivation-of-a-datadriven-followup-protocol-for-resected-skull-base-meningiomas-a-bayesian-analysis-neurooncology","title":{"rendered":"Derivation of a datadriven followup protocol for resected skull base meningiomas: a Bayesian analysis NeuroOncology"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/derivation-of-a-datadriven-followup-protocol-for-resected-skull-base-meningiomas-a-bayesian-analysis-neurooncology2.jpg\"><\/a><\/p>\n<p>Complete resection of skull base meningiomas (SBMs) is often limited by their proximity to critical neurovascular structures, potentially increasing the risk of postoperative progression. This study quantified long-term progression risk after SBM resection, identified predictors of progression, and developed a data-driven MRI surveillance protocol using Bayesian methods.<\/p>\n<p>Patients undergoing SBM resection between 2002 and 2020 at two neurosurgical centres were analysed. Kaplan\u2013Meier and Cox regression analyses were used to estimate intervention-free survival (IFS). Conditional probability modelling was used to derive an MRI surveillance schedule that maintained a \u2264 3% risk of progression requiring intervention, stratified by extent of resection.<\/p>\n<p>A total of 358 SBMs were included. Median age at diagnosis was 57 years (IQR 18), and 76.0% of patients were female. WHO Grade 1 tumours accounted for 80.3% of cases and Grade 2 for 19.7%. Median follow-up was 97 months (IQR 64\u2013128). Progression requiring re-intervention occurred in 14.1% of patients. Subtotal resection (STR) increased the risk of re-intervention (HR 2.62, 95% CI 1.30\u20135.30, <i>p<\/i> = 0.009), whereas higher comorbidity burden (HR 0.78, 95% CI 0.62\u20130.98, <i>p<\/i> = 0.038) and incidental presentation (HR 0.11, 95% CI 0.01\u20130.88, <i>p<\/i> = 0.038) were associated with lower risk. Conditional probability modelling demonstrated higher annual progression risk following STR, supporting more intensive imaging surveillance. Recommended MRI schedules were: gross total resection (GTR), scans at 3 months, 2, 5, 8, and 10 years; STR, scans at 3 months, 1 year, 18 months, annually from years 2\u20138, and at 10 years.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Complete resection of skull base meningiomas (SBMs) is often limited by their proximity to critical neurovascular structures, potentially increasing the risk of postoperative progression. This study quantified long-term progression risk after SBM resection, identified predictors of progression, and developed a data-driven MRI surveillance protocol using Bayesian methods. Patients undergoing SBM resection between 2002 and 2020 [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-241523","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241523","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=241523"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241523\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=241523"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=241523"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=241523"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}