{"id":241498,"date":"2026-07-24T12:04:17","date_gmt":"2026-07-24T17:04:17","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/07\/inside-the-worlds-first-age-reversal-trial-lifespan-with-dr-david-sinclair-s2-ep-4"},"modified":"2026-07-24T12:04:17","modified_gmt":"2026-07-24T17:04:17","slug":"inside-the-worlds-first-age-reversal-trial-lifespan-with-dr-david-sinclair-s2-ep-4","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/07\/inside-the-worlds-first-age-reversal-trial-lifespan-with-dr-david-sinclair-s2-ep-4","title":{"rendered":"Inside the World\u2019s First Age Reversal Trial | Lifespan with Dr. David Sinclair \u2014 S2, Ep. 4"},"content":{"rendered":"<p><\/p>\n<p><iframe style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/VZDgTe5NDkQ?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.<\/p>\n<p>We\u2019re building the world\u2019s largest longevity community: Join us at <a href=\"https:\/\/lifespan.com\">https:\/\/lifespan.com<\/a>.<\/p>\n<p>Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.<\/p>\n<p>In this episode of Lifespan, Dr. David Sinclair, A.O., Ph.D. \u2013 Professor of Genetics at Harvard Medical School and pioneer in longevity research \u2013 explores the science of eye aging, vision loss, and emerging strategies to preserve vision throughout life.<\/p>\n<p>Dr. Sinclair shares an inside update on ER-100, including his team\u2019s successful restoration of vision in non-human primates and the launch of the world\u2019s first FDA-cleared age reversal human clinical trial. This Phase 1 clinical trial will evaluate the safety of epigenetic cellular restoration as a therapy.<\/p>\n<p>Additionally, drawing on decades of research, Dr. Sinclair explains why the eyes may offer one of the earliest windows into biological aging, how everyday factors such as sleep position, alcohol consumption, and intraocular pressure influence long-term eye health, and what the latest evidence reveals about nutrition, supplements, and the connection between the eyes and the brain.<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2026\/07\/inside-the-worlds-first-age-reversal-trial-lifespan-with-dr-david-sinclair-s2-ep-4\">Continue reading \u201cInside the World\u2019s First Age Reversal Trial | Lifespan with Dr. David Sinclair \u2014 S2, Ep. 4\u201d | &gt;<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. We\u2019re building the world\u2019s largest longevity community: Join us at https:\/\/lifespan.com. Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks. In this episode [\u2026]<\/p>\n","protected":false},"author":367,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,269,47],"tags":[],"class_list":["post-241498","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241498","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/367"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=241498"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241498\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=241498"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=241498"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=241498"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}