{"id":241449,"date":"2026-07-23T20:14:19","date_gmt":"2026-07-24T01:14:19","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/07\/blurred-genome-boundaries-emerge-as-a-new-layer-of-alzheimers-biology"},"modified":"2026-07-23T20:14:19","modified_gmt":"2026-07-24T01:14:19","slug":"blurred-genome-boundaries-emerge-as-a-new-layer-of-alzheimers-biology","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/07\/blurred-genome-boundaries-emerge-as-a-new-layer-of-alzheimers-biology","title":{"rendered":"Blurred genome boundaries emerge as a new layer of Alzheimer\u2019s biology"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/blurred-genome-boundaries-emerge-as-a-new-layer-of-alzheimers-biology2.jpg\"><\/a><\/p>\n<p>Researchers from Carnegie Mellon University\u2019s School of Computer <i>Science<\/i>, the University of Pittsburgh School of Medicine and the University of Washington have shed new light on Alzheimer\u2019s disease that could point to new directions for treatment.<\/p>\n<p>In a paper published in <a href=\"https:\/\/doi.org\/10.1126\/science.adz1652\" target=\"_blank\"><i>Science<\/i><\/a>, researchers from SCS\u2019s Ray and Stephanie Lane Computational Biology Department, Pitt\u2019s Department of Neurobiology and collaborating institutions show that 3D genome architecture is organized differently in certain brain cells from people with Alzheimer\u2019s disease, uncovering a previously underexplored layer of the disease\u2019s biology.<\/p>\n<p>The research team linked genome folding to gene activity and brain tissue organization in Alzheimer\u2019s disease. The team did this with single-cell technology, spatial mapping of brain tissue and a new deep-learning model.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers from Carnegie Mellon University\u2019s School of Computer Science, the University of Pittsburgh School of Medicine and the University of Washington have shed new light on Alzheimer\u2019s disease that could point to new directions for treatment. In a paper published in Science, researchers from SCS\u2019s Ray and Stephanie Lane Computational Biology Department, Pitt\u2019s Department of [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,6],"tags":[],"class_list":["post-241449","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-robotics-ai"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241449","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=241449"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241449\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=241449"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=241449"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=241449"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}