{"id":241361,"date":"2026-07-22T12:06:51","date_gmt":"2026-07-22T17:06:51","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/07\/brain-penetrating-nanoparticles-ultrasound-and-microbubbles-show-promise-in-treating-glioblastoma"},"modified":"2026-07-22T12:06:51","modified_gmt":"2026-07-22T17:06:51","slug":"brain-penetrating-nanoparticles-ultrasound-and-microbubbles-show-promise-in-treating-glioblastoma","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/07\/brain-penetrating-nanoparticles-ultrasound-and-microbubbles-show-promise-in-treating-glioblastoma","title":{"rendered":"Brain-penetrating nanoparticles, ultrasound and microbubbles show promise in treating glioblastoma"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/brain-penetrating-nanoparticles-ultrasound-and-microbubbles-show-promise-in-treating-glioblastoma2.jpg\"><\/a><\/p>\n<p>University of Virginia Comprehensive Cancer Center scientists have developed a promising new experimental approach to targeting glioblastoma, the most common and deadliest brain cancer. The approach could overcome many of the limitations of treatments using existing drugs.<\/p>\n<p>UVA\u2019s Roger Abounader, MD, Ph.D., and colleagues have identified \u201cmicroRNAs\u201d that can simultaneously suppress multiple malfunctioning genes responsible for glioblastoma\u2019s formation and growth. The scientists use a combination of brain-penetrating nanoparticles, focused ultrasound waves and microbubbles to deliver the miRNAs through the brain\u2019s natural protective barrier\u2014a barrier that typically blocks treatments for tumors and neurodegenerative diseases. The study is <a href=\"http:\/\/www.jci.org\/articles\/view\/195639\" target=\"_blank\">published<\/a> in the Journal of Clinical Investigation.<\/p>\n<p>\u201cThis new approach could help target numerous molecules that promote cancer growth, including those for which no drugs exist, at the same time to achieve better therapies,\u201d said Abounader, a professor at UVA\u2019s School of Medicine, Department of Microbiology, Immunology and Cancer Biology, Comprehensive Cancer Center and Center for RNA Science and Medicine. \u201cWe are hoping to translate our findings into future clinical trials for patients with glioblastoma and other brain tumors.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>University of Virginia Comprehensive Cancer Center scientists have developed a promising new experimental approach to targeting glioblastoma, the most common and deadliest brain cancer. The approach could overcome many of the limitations of treatments using existing drugs. UVA\u2019s Roger Abounader, MD, Ph.D., and colleagues have identified \u201cmicroRNAs\u201d that can simultaneously suppress multiple malfunctioning genes responsible [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,4,47],"tags":[],"class_list":["post-241361","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-nanotechnology","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241361","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=241361"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241361\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=241361"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=241361"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=241361"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}